Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 24

  1. Cat.No. Product Name Information/Activity
  2. BCN5339 Quetiapine fumarate Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. Quetiapine fumarate chemical structure
  3. BCC3850 Risperidone Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Risperidone chemical structure
  4. BCC6790 (+)-UH 232 maleate 1217473-50-1 (+)-UH 232 maleate chemical structure
  5. BCC2072 Ziprasidone hydrochloride monohydrate Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. Ziprasidone hydrochloride monohydrate chemical structure
  6. BCC7838 Zotepine 26615-21-4 Zotepine chemical structure
  7. BCC6353 PAOPA 114200-31-6 PAOPA chemical structure
  8. BCC6756 7-Hydroxy-DPAT hydrobromide 76135-30-3 7-Hydroxy-DPAT hydrobromide chemical structure
  9. BCC6760 7-Hydroxy-PIPAT maleate 200722-46-9 7-Hydroxy-PIPAT maleate chemical structure
  10. BCN2181 Pramipexole dihydrochloride Pramipexole dihydrochloride is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. Pramipexole dihydrochloride chemical structure
  11. BCC7193 Eticlopride hydrochloride 97612-24-3 Eticlopride hydrochloride chemical structure

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