Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 29

  1. Cat.No. Product Name Information/Activity
  2. BCC6378 Talampanel(LY300164) Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Talampanel(LY300164) chemical structure
  3. BCC7171 UBP 282 544697-47-4 UBP 282 chemical structure
  4. BCC7455 YM 90K hydrochloride 154164-30-4 YM 90K hydrochloride chemical structure
  5. BCC7339 ZK 200775 Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. ZK 200775 chemical structure
  6. BCC6151 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor. CMPDA chemical structure
  7. BCC7532 CX 546 CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. CX 546 chemical structure
  8. BCC6759 Cyclothiazide 2259-96-3 Cyclothiazide chemical structure
  9. BCC5951 PEPA PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. PEPA chemical structure
  10. BCC6322 PF 4778574 PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. PF 4778574 chemical structure
  11. BCC6081 S 18986 S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests. S 18986 chemical structure

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