Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 26

  1. Cat.No. Product Name Information/Activity
  2. BCC2054 WAY-100635 maleate salt WAY-100635 maleate salt is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate salt has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate salt is also a potent dopamine D4 receptor agonist. WAY-100635 maleate salt chemical structure
  3. BCC7440 Fananserin Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor. Fananserin chemical structure
  4. BCC5696 L-741,742 hydrochloride 874882-93-6 L-741,742 hydrochloride chemical structure
  5. BCC5695 L-745,870 trihydrochloride 866021-03-6 L-745,870 trihydrochloride chemical structure
  6. BCC7702 PD 168568 dihydrochloride 210688-56-5 PD 168568 dihydrochloride chemical structure
  7. BCC7467 PNU 96415E 170856-41-4 PNU 96415E chemical structure
  8. BCC7879 Sonepiprazole 170858-33-0 Sonepiprazole chemical structure
  9. BCC7636 NGD 94-1 178928-68-2 NGD 94-1 chemical structure
  10. BCC6926 (RS)-AMPA hydrobromide 171259-81-7 (RS)-AMPA hydrobromide chemical structure
  11. BCC6582 (R)-AMPA 83654-13-1 (R)-AMPA chemical structure

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