PangelinCAS# 33783-80-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 33783-80-1 | SDF | Download SDF |
| PubChem ID | 44144315 | Appearance | Powder |
| Formula | C16H14O5 | M.Wt | 286.28 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(2R)-2-hydroxy-3-methylbut-3-enoxy]furo[3,2-g]chromen-7-one | ||
| SMILES | CC(=C)C(COC1=C2C=CC(=O)OC2=CC3=C1C=CO3)O | ||
| Standard InChIKey | BVMOMQJYQYBMKL-LBPRGKRZSA-N | ||
| Standard InChI | InChI=1S/C16H14O5/c1-9(2)12(17)8-20-16-10-3-4-15(18)21-14(10)7-13-11(16)5-6-19-13/h3-7,12,17H,1,8H2,2H3/t12-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Pangelin Dilution Calculator
Pangelin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4931 mL | 17.4654 mL | 34.9308 mL | 69.8617 mL | 87.3271 mL |
| 5 mM | 0.6986 mL | 3.4931 mL | 6.9862 mL | 13.9723 mL | 17.4654 mL |
| 10 mM | 0.3493 mL | 1.7465 mL | 3.4931 mL | 6.9862 mL | 8.7327 mL |
| 50 mM | 0.0699 mL | 0.3493 mL | 0.6986 mL | 1.3972 mL | 1.7465 mL |
| 100 mM | 0.0349 mL | 0.1747 mL | 0.3493 mL | 0.6986 mL | 0.8733 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxic coumarins from the root of Angelica dahurica.[Pubmed:15646793]
Arch Pharm Res. 2004 Dec;27(12):1211-5.
Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, oxypeucedanin hydrate acetonide (7) was isolated for the first time from this plant. Cytotoxicity of coumarins isolated were determined in vitro against L1210, HL-60, K562, and B16F10 tumor cell lines by MTT method. Pangelin (5) and oxypeucedanin hydrate acetonide (7) showed a potent cytotoxic activity with the IC50 values of 8.6 to 14.6 microg/mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines.
Pangelin, an antimycobacterial coumarin from Ducrosia anethifolia.[Pubmed:14648403]
Planta Med. 2003 Oct;69(10):956-9.
The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin ( 1) and the prenylated furanocoumarin Pangelin [5-[2"( R)-hydroxy-3"-methyl-3"-butenyloxy]furocoumarin] ( 2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 microg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full (1)H- and (13)C-NMR data for these natural products.
