PTP1B-IN-1CAS# 612530-44-6 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 612530-44-6 | SDF | Download SDF |
| PubChem ID | 4369452 | Appearance | Powder |
| Formula | C8H8N2O3S | M.Wt | 212.23 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | PTP1B inhibitor | ||
| Solubility | DMSO : ≥ 38 mg/mL (179.05 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 1,1-dioxo-5-phenyl-1,2,5-thiadiazolidin-3-one | ||
| SMILES | C1C(=O)NS(=O)(=O)N1C2=CC=CC=C2 | ||
| Standard InChIKey | LDCZCUKQWRZSDT-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H8N2O3S/c11-8-6-10(14(12,13)9-8)7-4-2-1-3-5-7/h1-5H,6H2,(H,9,11) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
PTP1B-IN-1 Dilution Calculator
PTP1B-IN-1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.7119 mL | 23.5593 mL | 47.1187 mL | 94.2374 mL | 117.7967 mL |
| 5 mM | 0.9424 mL | 4.7119 mL | 9.4237 mL | 18.8475 mL | 23.5593 mL |
| 10 mM | 0.4712 mL | 2.3559 mL | 4.7119 mL | 9.4237 mL | 11.7797 mL |
| 50 mM | 0.0942 mL | 0.4712 mL | 0.9424 mL | 1.8847 mL | 2.3559 mL |
| 100 mM | 0.0471 mL | 0.2356 mL | 0.4712 mL | 0.9424 mL | 1.178 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
References:
[1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.
[2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.
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PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
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