Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucosideCAS# 199796-12-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 199796-12-8 | SDF | Download SDF |
| PubChem ID | 124578359 | Appearance | Powder |
| Formula | C26H30O13 | M.Wt | 550.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | iquiritigeninyl-7-O--D-furanapiosyl-4'-O--D-glucopyranoside | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S)-7-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one | ||
| SMILES | C1C(OC2=C(C1=O)C=CC(=C2)OC3C(C(CO3)(CO)O)O)C4=CC=C(C=C4)OC5C(C(C(C(O5)CO)O)O)O | ||
| Standard InChIKey | KEABDZDFSMGRQX-DWMQJYMWSA-N | ||
| Standard InChI | InChI=1S/C26H30O13/c27-9-19-20(30)21(31)22(32)24(39-19)36-13-3-1-12(2-4-13)17-8-16(29)15-6-5-14(7-18(15)38-17)37-25-23(33)26(34,10-28)11-35-25/h1-7,17,19-25,27-28,30-34H,8-11H2/t17-,19+,20+,21-,22+,23-,24+,25-,26+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial injury in COPD. |
| Targets | TNF-α | TGF-β/Smad |
| In vivo | Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. [Pubmed: 21631586]Fundam Clin Pharmacol. 2012 Aug;26(4):473-83.Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD). |
Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside Dilution Calculator
Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8165 mL | 9.0827 mL | 18.1653 mL | 36.3306 mL | 45.4133 mL |
| 5 mM | 0.3633 mL | 1.8165 mL | 3.6331 mL | 7.2661 mL | 9.0827 mL |
| 10 mM | 0.1817 mL | 0.9083 mL | 1.8165 mL | 3.6331 mL | 4.5413 mL |
| 50 mM | 0.0363 mL | 0.1817 mL | 0.3633 mL | 0.7266 mL | 0.9083 mL |
| 100 mM | 0.0182 mL | 0.0908 mL | 0.1817 mL | 0.3633 mL | 0.4541 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury.[Pubmed:21631586]
Fundam Clin Pharmacol. 2012 Aug;26(4):473-83.
Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD). In this study, we hypothesized that liquiritin apioside (LA), a main flavonoid component from Glycyrrhiza uralensis, had antioxidant properties by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress. A549 cells were treated with cigarette smoke extract (CSE) and/or LA. ICR mice were exposed to cigarette smoke (CS) for four days with increasing exposure time for up to 6 h per day to elicit epithelial cells injury. One hour before smoke exposure, mice were treated with LA by gavage; 18 h after the last CS exposure all examinations were performed. Treatment with LA concentration-dependently prevented CSE-induced cytotoxicity, increase of TGF-beta and TNF-alpha mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation. Lung sections of the CS-exposed LA treated mice showed an apparently reduced pulmonary inflammation and a significant inhibitory effect on mucus containing goblet cells in the large airways. Furthermore, the CS-induced pulmonary release of TGF-beta, TNF-alpha and myeloperoxidase activity was reduced, and superoxide dismutase activity was enhanced.These results indicate that protective roles of LA on CS-induced the lung epithelial cell injury are mediated by inhibiting TGF-beta and TNF-alpha expression and increasing anti-oxidative levels of GSH, suggesting that LA might be effective as protective agent against epithelial injury in COPD.
