Lidocaine hydrochlorideCAS# 73-78-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 73-78-9 | SDF | Download SDF |
| PubChem ID | 6314 | Appearance | Powder |
| Formula | C14H23ClN2O | M.Wt | 270.8 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Lignocaine hydrochloride | ||
| Solubility | H2O : ≥ 100 mg/mL (369.28 mM) DMSO : ≥ 100 mg/mL (369.28 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride | ||
| SMILES | CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl | ||
| Standard InChIKey | IYBQHJMYDGVZRY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Lidocaine hydrochloride Dilution Calculator
Lidocaine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6928 mL | 18.4638 mL | 36.9276 mL | 73.8552 mL | 92.3191 mL |
| 5 mM | 0.7386 mL | 3.6928 mL | 7.3855 mL | 14.771 mL | 18.4638 mL |
| 10 mM | 0.3693 mL | 1.8464 mL | 3.6928 mL | 7.3855 mL | 9.2319 mL |
| 50 mM | 0.0739 mL | 0.3693 mL | 0.7386 mL | 1.4771 mL | 1.8464 mL |
| 100 mM | 0.0369 mL | 0.1846 mL | 0.3693 mL | 0.7386 mL | 0.9232 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx. Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself. Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).
References:
[1]. VAN DER Wal S, et al. Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice. Acta Anaesthesiol Scand. 2014 Oct 14.
[2]. Acevedo-Arcique CM, et al. Lidocaine, dexmedetomidine and their combination reduce isoflurane minimum alveolar concentration in dogs. PLoS One. 2014 Sep 18;9(9):e106620.
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