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Daphnetin 7-methyl ether

CAS# 19492-03-6

Daphnetin 7-methyl ether

Catalog No. BCN2734----Order now to get a substantial discount!

Product Name & Size Price Stock
Daphnetin 7-methyl ether:5mg $66.00 In Stock
Daphnetin 7-methyl ether:10mg Please Inquire Instock
Daphnetin 7-methyl ether:20mg Please Inquire Instock
Daphnetin 7-methyl ether:50mg Please Inquire Instock
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Quality Control of Daphnetin 7-methyl ether

Quality Control & MSDS

Number of papers citing our products

Chemical structure

Daphnetin 7-methyl ether

3D structure

Chemical Properties of Daphnetin 7-methyl ether

Cas No. 19492-03-6 SDF Download SDF
PubChem ID 146487 Appearance Cryst.
Formula C10H8O4 M.Wt 192.17
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 8-hydroxy-7-methoxychromen-2-one
SMILES COC1=C(C2=C(C=C1)C=CC(=O)O2)O
Standard InChIKey KIGCGZUAVODHMD-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H8O4/c1-13-7-4-2-6-3-5-8(11)14-10(6)9(7)12/h2-5,12H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Daphnetin 7-methyl ether

The roots of Wikstroemia indica (Linn.) C. A. Mey.

Biological Activity of Daphnetin 7-methyl ether

DescriptionDaphnetin 7-methyl ether has anti-inflammatory activity.
TargetsImmunology & Inflammation related
In vitro

In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis[Reference: WebLink]

Article first published online: 17 JUN 2015

The C-8 phenol group is essential to exert the bioactivities of daphnetin, but it is readily conjugated with glucuronic acid prior to excretion.
METHODS AND RESULTS:
In this study, Daphnetin 7-methyl ether (7M-DNP) was used to investigate the effect of 7-methyl substitution on daphnetin glucuronidation in human/rat liver (HLM/RLM) and intestine (HIM/RIM) microsomes, and recombinant UDP-glucuronosyltransferases (UGTs). Compared with daphnetin, the Vmax/Km values of 7M-DNP via 8-O-glucuronidation were 2.1-fold lower in HLM, 1.7-fold lower in HIM, and 2.4-fold lower in RLM, suggesting an improvement in metabolic stability. Different from daphnetin 8-O-glucuronidation exclusively catalyzed by UGT1A6 and UGT1A9, UGT1A1, -1A3, -1A7, -1A8, and -1A9 showed glucuronidation activity toward Daphnetin 7-methyl ether . Kinetics studies, chemical inhibition, and the relative activity factor approach were used to demonstrate that UGT1A9 was mainly responsible for the reaction in HLM, whereas UGT1A1 was a primary contributor in HIM. The Vmax/Km values of Daphnetin 7-methyl ether glucuronidation in HLM and HIM were 0.61–0.74-fold lower than those of rat, suggesting the differences between the two species.
CONCLUSIONS:
The bioactivity analysis demonstrated that Daphnetin 7-methyl ether had an anti-inflammatory activity comparable to that of daphnetin.

Daphnetin 7-methyl ether Dilution Calculator

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Preparing Stock Solutions of Daphnetin 7-methyl ether

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.2037 mL 26.0186 mL 52.0373 mL 104.0745 mL 130.0931 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL 20.8149 mL 26.0186 mL
10 mM 0.5204 mL 2.6019 mL 5.2037 mL 10.4075 mL 13.0093 mL
50 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.0815 mL 2.6019 mL
100 mM 0.052 mL 0.2602 mL 0.5204 mL 1.0407 mL 1.3009 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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