Products with Toxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3766 | Kansuinine B |
| 1. Kansuinine B shows cytotoxic activity. 2. Kansuinine B shows analgesic activity. 3. Treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects. | |
| BCN3767 | 3-O-(2'E,4'Z-Decadienoyl)ingenol |
| 1. 20-O-(2′E,4′Z-decadienoyl)ingenol, one toxic terpenoid from raw Gansui. Kansuiphorin C and 3-O-(2′E,4′Z-decadienoyl)-ingenol exhibit significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8 and 89.5±5.5 uM. 2. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball. | |
| BCN3768 | 3-O-(2'E,4'E-Decadienoyl)ingenol |
| 1. 3-O-(2'E,4'E-Decadienoyl)ingenol , one toxic terpenoid from raw Gansui. 2. 3-O-(2′E,4′E-decadienoyl)-ingenol and 3-O-(2′E,4′Z-decadienoyl)-20-O-acetyl-ingenol show cytotoxicity on Namalwa cells with IC 50 values of 7.6 and 5.2 umol·L-1, respectively. | |
| BCN4139 | 2,4-Dihydroxyphenylacetic acid |
| 1. 2,4-Dihydroxyphenylacetic acid is a functional moiety in the toxin molecule and the biological action of spider toxin is explained by direct interaction with an Fe-S center which is known to play an important role for the glutamate binding. | |
| BCN4227 | Spathulenol |
| 1. Spathulenol has immunomodulatory effect. 2. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway. 3. Spathulenol presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer and therefore is worthy for further in vivo studies. | |
