Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2539 | Pterostilbene |
| Pterostilbene acts as a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, it has been implicated in anticarcinogenesis, antioxidant, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. Pterostilbene downregulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK. Pterostilbene may protect HUVECs against oxLDL-induced apoptosis by downregulating LOX-1-mediated activation through a pathway involving oxidative stress, p53, mitochondria, cytochrome c and caspase protease. | |
| BCN2549 | Dehydrocavidine |
| 1. Dehydrocorydaline has antitumor activity. 2. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP. 3. Dehydrocorydaline reduces the viability of macrophage-derived RAW264.7 cells and primary macrophages in the presence of LPS. 4. Dehydrocorydaline inhibits the elevation of mitochondrial membrane potential and induces ATP depletion in LPS-stimulated macrophages but neither affects basal mitochondrial membrane potential nor ATP content in non-stimulated macrophages. | |
| BCN2550 | Glaucine |
| Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of human breast cancer cells by MMP-9 inhibitory activity, attenuating IκBα and NF-κB activities. | |
| BCN2556 | Eburicoic acid |
| 1. Eburicoic acid has significant anti-liver cancer effects and more distinctive mechanisms. 2. Eburicoic acid and TR2 protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. 3. Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity. | |
| BCN2558 | Tetrahydrocoptisine |
| Tetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways.Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression. | |
