Pain and Inflammation Research

Although separate conditions, pain and inflammation are nearly always associated with each other. Pain is defined by the International Association for the Study of Pain (IASP) as 'an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage'. Inflammation is the tissue's immunologic response to injury, characterized by mobilization of white blood cells and antibodies, swelling, and fluid accumulation.

Pain and Inflammation Research Products Areas

Products for Pain and Inflammation Research - Page 34

Cat.No. Product Name Information/Activity
BCC6023 4-IPP 4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).
BCC5427 ISO-1 ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
BCC7960 (D)-(+)-Neopterin D-(+)-Neopterin, a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.
BCC5086 Pirfenidone Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities.
BCC7236 SKF 86002 dihydrochloride 116339-68-5
BCC4961 Suplatast Tosylate Suplatast Tosilate (IPD 1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production.
BCC2248 Thalidomide Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
BCC8088 AEG 3482 63735-71-7
BCC8089 BI 78D3 BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM).
BCC7982 CEP 1347 156177-65-0