Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 41

  1. Cat.No. Product Name Information/Activity
  2. BCC5705 Picrotoxin Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) causes overstimulation and induces convulsions. Picrotoxin chemical structure
  3. BCC7266 SCS 3232-36-8 SCS chemical structure
  4. BCC6997 SR 95531 hydrobromide Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor. SR 95531 hydrobromide chemical structure
  5. BCC7510 TB 21007 207306-50-1 TB 21007 chemical structure
  6. BCC7471 U 93631 U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. U 93631 chemical structure
  7. BCC5521 Emapunil Emapunil(AC-5216;XBD-173) is a translocator protein [TSPO (18 kDa)] ligand. Emapunil chemical structure
  8. BCC7711 Bretazenil 84379-13-5 Bretazenil chemical structure
  9. BCC6635 β-CCB 84454-35-3 β-CCB chemical structure
  10. BCC7162 CL 218872 66548-69-4 CL 218872 chemical structure
  11. BCC6671 Dihydroergotoxine mesylate Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Dihydroergotoxine mesylate chemical structure

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