Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 5

  1. Cat.No. Product Name Information/Activity
  2. BCN5607 Resveratrol Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol chemical structure
  3. BCC7111 SC 560 SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM. SC 560 chemical structure
  4. BCC5948 SC 58125 162054-19-5 SC 58125 chemical structure
  5. BCC7809 SC 236 170569-86-5 SC 236 chemical structure
  6. BCC4861 Sulindac Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2. Sulindac chemical structure
  7. BCC7391 Talniflumate 66898-62-2 Talniflumate chemical structure
  8. BCC7419 Tenidap Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor. Tenidap chemical structure
  9. BCC4441 Valdecoxib Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. Valdecoxib chemical structure
  10. BCC1327 Acamprosate calcium Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. Acamprosate calcium chemical structure
  11. BCC4503 (R)-baclofen (R)-Baclofen(STX209) is a selective GABAB receptor agonist. (R)-baclofen chemical structure

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