Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 2

  1. Cat.No. Product Name Information/Activity
  2. BCN2702 Gossypol Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively. Gossypol chemical structure
  3. BCC2397 Muristerone A Stimulates Bcl-XL mRNA transcription; antiapoptotic Muristerone A chemical structure
  4. BCC2398 SU 9516 SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also shows inhibitory effects on CDK1 and CDK4, with IC50s of 40, 200 nM, respectively. SU 9516 chemical structure
  5. BCC2356 AZ 10417808 Selective non-peptide caspase-3 inhibitor AZ 10417808 chemical structure
  6. BCC1126 Z-VAD-FMK Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. Z-VAD-FMK chemical structure
  7. BCC2358 Ac-IEPD-AFC Ac-IEPD-AFC (IEPD) is a substrate of Granzyme B. Ac-IEPD-AFC chemical structure
  8. BCC2359 Ac-LEHD-AFC 210345-03-2 Ac-LEHD-AFC chemical structure
  9. BCN1552 Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3,Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin chemical structure
  10. BCC3600 PAC-1 PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM. PAC-1 chemical structure
  11. BCC2360 PETCM PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells. PETCM chemical structure

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