Myocardial Infarction Research

Myocardial infarction (MI) - more commonly referred to as a heart attack - is an acute event caused by the interruption of blood supply to regions of the heart, leading to myocardial necrosis. Infarction of a substantial area of the myocardium can disrupt normal conductance of the heart, leading to cardiac arrest.In the majority of cases, an MI is immediately preceded by the presence of an occlusive thrombus within a coronary artery, blocking blood flow to the downstream tissue. The most common cause of an occlusive thrombus within a coronary artery is the rupture of an atherosclerotic plaque. However, the occlusion of a coronary artery may also result from coronary embolism. This can occur in patients following stent placement, angioplasty, and coronary artery bypass grafting.

Myocardial Infarction Research Products Targets

Products for Myocardial Infarction Research - Page 2

Cat.No. Product Name Information/Activity
BCC1920 Salmeterol xinafoate Salmeterol xinafoate is a long-acting beta-2 adrenergic receptor (β2AR) agonist, with Ki of 1.5 nM for WT β2AR, and used for asthma treatment.
BCC6911 Zinterol hydrochloride Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.
BCC4029 ICI 118,551 hydrochloride ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
BCC6860 BRL 37344, sodium salt BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice.
BCC6949 CGP 12177 hydrochloride 64208-32-8
BCC7091 CL 316243 disodium salt 151126-84-0
BCC5688 ICI 215,001 hydrochloride 140850-02-8
BCC7282 L-755,507 L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM.
BCC4814 (+,-)-Octopamine HCl Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems.
BCC6881 Pindolol Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).