Cardiovascular Research

The cardiovascular, or circulatory, system is a closed elastic circuit consisting of the heart, blood vessels (arteries, capillaries and veins) and the blood. The primary function is to pump oxygenated blood to the tissues throughout the body and reabsorb waste carbon dioxide for its removal. This function is performed by the use of pulmonary and systemic circulation.

Cardiovascular Research Products Areas

Products for Cardiovascular Research - Page 14

Cat.No. Product Name Information/Activity
BCC7288 STEARDA 105955-10-0
BCC6735 2-TEDC 132465-10-2
BCC2515 Zileuton Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
BCC7412 Fexaramine Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.
BCC3790 GW3965 HCl GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 and 30 nM for hLXRα and hLXRβ , respectively.
BCC4500 GW4064 GW 4064 is a potent FXR agonist with an EC50 of 65 nM.
BCN2750 27-Hydroxycholesterol 27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.
BCC1178 T0901317 T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively[1,2]. T0901317 induces its anti-proliferative and cytotoxic effects via an LXR-independent mechanism. T0901317 significantly suppresses cell proliferation and induces programmed cell death in a dose- and time-dependent manner. T0901317 can protect mice from high fat diet-induced obesity and insulin resistance.
BCC4273 LXR-623 LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC50s of 24 nM and 179 nM, respectively.
BCC2370 ARP 100 ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).