TiratricolCAS# 51-24-1 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 51-24-1 | SDF | Download SDF |
| PubChem ID | 5803 | Appearance | Powder |
| Formula | C14H9I3O4 | M.Wt | 621.93 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | 3,3',5-Triiodothyroacetic acid | ||
| Solubility | DMSO : ≥ 42 mg/mL (67.53 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid | ||
| SMILES | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O | ||
| Standard InChIKey | UOWZUVNAGUAEQC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H9I3O4.Na/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20;/h1-4,6,18H,5H2,(H,19,20);/q;+1/p-1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects. |
Tiratricol Dilution Calculator
Tiratricol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6079 mL | 8.0395 mL | 16.079 mL | 32.158 mL | 40.1974 mL |
| 5 mM | 0.3216 mL | 1.6079 mL | 3.2158 mL | 6.4316 mL | 8.0395 mL |
| 10 mM | 0.1608 mL | 0.8039 mL | 1.6079 mL | 3.2158 mL | 4.0197 mL |
| 50 mM | 0.0322 mL | 0.1608 mL | 0.3216 mL | 0.6432 mL | 0.8039 mL |
| 100 mM | 0.0161 mL | 0.0804 mL | 0.1608 mL | 0.3216 mL | 0.402 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.
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Tiratricol-induced periodic paralysis: a review of nutraceuticals affecting thyroid function.[Pubmed:21803722]
Endocr Pract. 2011 Jul-Aug;17(4):610-5.
OBJECTIVE: To review the potential adverse effects of thyroid hormone-based nutraceuticals and describe a case of thyrotoxic periodic paralysis (TPP) after abuse of a dietary supplement containing 3,5,3'-triiodothyroacetic acid (Tiratricol). METHODS: We review the literature on potential dangers and therapeutic misadventures of thyroid hormone-based nutraceuticals and present the clinical, laboratory, and radiologic data of a bodybuilder in whom hypokalemic TPP developed after use of "Triax Metabolic Accelerator". RESULTS: A 23-year-old white man developed lower extremity paralysis, diaphoresis, and palpitations in the setting of low serum potassium levels. Laboratory results showed suppressed thyroid-stimulating hormone, low levels of free and total thyroxine, low total triiodothyronine level, and very low 24-hour radioiodine uptake. The patient ultimately admitted to taking a supplement containing Tiratricol for approximately 2 months, and hypokalemic TPP was diagnosed. He was treated with potassium supplementation and a beta-adrenergic blocking agent, which completely resolved his symptoms. Results of thyroid function tests normalized or approached normal 1 week after hospitalization, and future use of dietary supplements was strongly discouraged. Despite 2 warnings by the US Food and Drug Administration, products containing Tiratricol are still available for sale on the Internet. CONCLUSION: This report illustrates both an unusual adverse effect of a nutraceutical containing Tiratricol and the importance of educating our patients about the risks versus benefits of using these widely available but loosely regulated products.
Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell.[Pubmed:18844678]
Chem Biol Drug Des. 2008 Oct;72(4):320-8.
The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially comprised the Prestwick Chemical library, as sources of bacterial endotoxin neutralizers. We identified 3,3',5-triiodo-thyroacetic acid (Tiratricol) as a non-antibacterial compound that neutralizes the toxic lipopolysaccharide.
