TioconazoleCAS# 65899-73-2 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 65899-73-2 | SDF | Download SDF |
| PubChem ID | 5482 | Appearance | Powder |
| Formula | C16H13Cl3N2OS | M.Wt | 387.71 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (257.92 mM) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole | ||
| SMILES | C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=C(SC=C3)Cl | ||
| Standard InChIKey | QXHHHPZILQDDPS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Tioconazole Dilution Calculator
Tioconazole Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5792 mL | 12.8962 mL | 25.7925 mL | 51.5849 mL | 64.4812 mL |
| 5 mM | 0.5158 mL | 2.5792 mL | 5.1585 mL | 10.317 mL | 12.8962 mL |
| 10 mM | 0.2579 mL | 1.2896 mL | 2.5792 mL | 5.1585 mL | 6.4481 mL |
| 50 mM | 0.0516 mL | 0.2579 mL | 0.5158 mL | 1.0317 mL | 1.2896 mL |
| 100 mM | 0.0258 mL | 0.129 mL | 0.2579 mL | 0.5158 mL | 0.6448 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vitro synergy testing of anidulafungin with fluconazole, tioconazole, 5-flucytosine and amphotericin B against some Candida spp.[Pubmed:22530916]
Med Chem. 2012 Jul;8(4):690-8.
In this paper the authors investigated a synergistic antimycotic effect between four antifungal drugs Amphotericin B, Fluconazole, Tioconazole, and Flucytosine individually combined with Anidulafungin compound. This latter is considered a drug of choice in the treatment of fungal infections; it has good activity both in vitro and in vivo against yeasts and moulds, as Candida and Aspergillus. The goal of this study was to evaluate the in vitro interaction of Anidulafungin in the synergic combinations with previous reported drugs against 12 Candida strains according to CLSI M27-A3 protocol. A synergistic interaction was observed against the most antifungal strains; in particular an increasing of the antimycotic efficacy was obtained from the association between Anidulafungin and Amphotericin B or Fluconazole (Mixture 4:6). In contrast the association Tioconazole/Anidulafungin was less effective on fungal species growth. The antimycotics MIC reduction values were more evident against some strains as C. glabrata, C. krusei, C. tropicalis and C. parapsilosis.
Spray-dried powders improve the controlled release of antifungal tioconazole-loaded polymeric nanocapsules compared to with lyophilized products.[Pubmed:26652443]
Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:875-884.
This work aimed to obtain solid formulations from polymeric nanocapsules and nanoemulsions containing Tioconazole, a broad spectrum antifungal drug. Two dehydration methods were used: spray-drying and freeze drying, using lactose as adjuvant (10%, w/v). The liquid formulations had a mean particle size around 206 nm and 182 nm for nanocapsules and nanoemulsions, respectively, and an adequate polydispersity index. Tioconazole content was close to the theoretical amount (1.0 mg/mL). After drying, the content ranged between 98 and 102%with a mean nanometric size of the dried products after redispersion. Scanning electron microscopy showed that the particles are rounded, sphere-shaped for the dried products obtained by spray-drying, and shapeless and irregular shapes for those obtained by freeze-drying. In the microbiological evaluation, all dried products remained active against the yeast Candida albicans when compared to the original systems. The dried products obtained by spray-drying from nanocapsules presented better control of the Tioconazole release when compared to the freeze-drying products.
Molecular properties of oxyconazole and tioconazole as the criteria for their bioavailability estimation.[Pubmed:18536184]
Acta Pol Pharm. 2008 Jan-Feb;65(1):123-4.
The use of hydration and solvatation free enthalpies (DeltaG(h), DeltaG(s)) as parameters describing water solubility and permeability of drugs was proved to be suitable quantities. The free enthalpies of hydration and solvation by water and chlorobenzene molecules at the Hartree-Fock (6-31G*) level applying PCM model were calculated for oxyconazole and Tioconazole. The oxyconazole and Tioconazole differ in water and chlorobenzene solubility, what is reflected in calculated DeltaG values and electrostatic potential. These characteristics discriminate both compounds with respect to water solubility and permeability. It may be concluded that the DeltaG values of hydration and solvation adequately reflect the water solubility and permeability of oxyconazole and Tioconazole.
