Danshenxinkun A

CAS# 65907-75-7

Danshenxinkun A

Catalog No. BCN2469----Order now to get a substantial discount!

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Danshenxinkun A:50mg Please Inquire In Stock
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Quality Control of Danshenxinkun A

Quality Control & MSDS

Number of papers citing our products

Chemical structure

Danshenxinkun A

3D structure

Chemical Properties of Danshenxinkun A

Cas No. 65907-75-7 SDF Download SDF
PubChem ID 149138 Appearance Orange-yellow powder
Formula C18H16O4 M.Wt 296.32
Type of Compound Diterpenoids Storage Desiccate at -20°C
Synonyms Tanshinone VI
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-hydroxy-2-(1-hydroxypropan-2-yl)-8-methylphenanthrene-3,4-dione
SMILES CC1=CC=CC2=C1C=CC3=C2C(=O)C(=O)C(=C3O)C(C)CO
Standard InChIKey GRGPQNRHXNRJFL-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H16O4/c1-9-4-3-5-12-11(9)6-7-13-15(12)18(22)17(21)14(16(13)20)10(2)8-19/h3-7,10,19-20H,8H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Danshenxinkun A

The roots of Salvia miltiorrhiza Bge.

Biological Activity of Danshenxinkun A

DescriptionDanshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental adaptation and nervous system. Oleoyl danshenxinkun A also selectively inhibits rabbit platelet aggregation induced by arachidonic acid.
In vitro

Rapidly identify compounds from danshen by using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer and predict its mechanisms of intervening thrombotic diseases.[Reference: WebLink]

Journal of Liquid Chromatography & Related Technologies, 2019,42:115-121.

Danshen, having good efficacies of dilating the coronary artery, improving microcirculation and preventing thrombosis, is widely used in clinic to treat various thrombotic diseases in China. This study aimed to identifying and analyzing the chemical constituents of Danshen from different planting areas based on UHPLC-LTQ-Orbitrap MS and comprehensively predicting the potential pharmacological targets and pathways of the main chemical constituents that involve in the treatment of thrombotic diseases by using network pharmacology.
METHODS AND RESULTS:
As a result, we identified 870 single peaks from total ion current and accurately identified 19 compounds from Danshen in this study. Further analysis showed that these compounds had three types of accumulation patterns and contents of most compounds had significant differences in samples from different planting areas. Network pharmacological analysis showed that Tanshinone IIA, Tanshinone IIB, Dehydromiltirone, Cryptotanshinone, Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone might intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental adaptation and nervous system.
CONCLUSIONS:
This study provides a scientific basis for exploring the mechanism of Danshen in treating thrombotic diseases and controlling the quality of Danshen-related preparations.

Protocol of Danshenxinkun A

Structure Identification
Journal of Natural Products, 2001, 64(5):648-650.

Two new fatty diterpenoids from Salvia miltiorrhiza.[Reference: WebLink]


METHODS AND RESULTS:
Two new fatty abietane diterpenoids, oleoyl neocryptotanshinone (1) and oleoyl Danshenxinkun A (2), were isolated as minor components from the roots of Salvia miltiorrhiza. Their structures were established on the basis of spectral evidence.
CONCLUSIONS:
In preliminary tests, they selectively inhibited rabbit platelet aggregation induced by arachidonic acid.

Danshenxinkun A Dilution Calculator

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Danshenxinkun A Molarity Calculator

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Preparing Stock Solutions of Danshenxinkun A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3747 mL 16.8737 mL 33.7473 mL 67.4946 mL 84.3683 mL
5 mM 0.6749 mL 3.3747 mL 6.7495 mL 13.4989 mL 16.8737 mL
10 mM 0.3375 mL 1.6874 mL 3.3747 mL 6.7495 mL 8.4368 mL
50 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.3499 mL 1.6874 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.6749 mL 0.8437 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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