SteviolbiosideCAS# 41093-60-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 41093-60-1 | SDF | Download SDF |
| PubChem ID | 90472460 | Appearance | White powder |
| Formula | C32H50O13 | M.Wt | 642.73 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 250 mg/mL (388.97 mM; Need ultrasonic) | ||
| SMILES | CC12CCCC(C1CCC34C2CCC(C3)(C(=C)C4)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)(C)C(=O)O | ||
| Standard InChIKey | OMHUCGDTACNQEX-QEBBIIKSSA-N | ||
| Standard InChI | InChI=1S/C32H50O13/c1-15-11-31-9-5-18-29(2,7-4-8-30(18,3)28(40)41)19(31)6-10-32(15,14-31)45-27-25(23(38)21(36)17(13-34)43-27)44-26-24(39)22(37)20(35)16(12-33)42-26/h16-27,33-39H,1,4-14H2,2-3H3,(H,40,41)/t16-,17-,18+,19+,20-,21-,22+,23+,24-,25-,26+,27+,29-,30-,31+,32-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Steviolbioside is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside could be a potential remedy for human breast cancer. 2. Steviolbioside exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro. |
| Targets | Antifection |
Steviolbioside Dilution Calculator
Steviolbioside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5559 mL | 7.7793 mL | 15.5586 mL | 31.1173 mL | 38.8966 mL |
| 5 mM | 0.3112 mL | 1.5559 mL | 3.1117 mL | 6.2235 mL | 7.7793 mL |
| 10 mM | 0.1556 mL | 0.7779 mL | 1.5559 mL | 3.1117 mL | 3.8897 mL |
| 50 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.6223 mL | 0.7779 mL |
| 100 mM | 0.0156 mL | 0.0778 mL | 0.1556 mL | 0.3112 mL | 0.389 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Validation of HPLC-UV method for determination of minor glycosides contained in Stevia rebaudiana Bertoni leaves.[Pubmed:25296637]
Biomed Chromatogr. 2015 May;29(5):733-8.
Leaves of Stevia rebaudiana contain glycosides with sweetness and biological activity. However besides the major glycosides, there are other glycosides within extracts that may contribute to its activity, and therefore it is important to quantify them. In this work, an isocratic HPLC method was validated for determination of dulcoside A, Steviolbioside, rebaudioside C and rebaudioside B. An HPLC method was performed using a C18 column (250 x 4.6 mm, particle size 5 microm) and a UV detector set at 210 nm. The mobile phase consisted of a 32:68 (v/v) mixture of acetonitrile and sodium phosphate buffer (10 mmol/L, pH 2.6), set to a flow rate of 1.0 mL/min. The calculated parameters were: sensitivity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy and precision. The calibration curves were linear over the working range 25-150 microg/mL, with coefficient of correlation of >/=0.99 and coefficient of determination of >/=0.98. The LOD was 5.68-8.81 microg/mL, while the LOQ was 17.21-26.69 microg/mL. The percentage recoveries of fortified samples were 100 +/- 10% and precision, relative standard deviation, was <10%. The method validation showed accuracy, linearity and precision; therefore this method can be applied for quantitative analysis of minor steviol glycosides in S. rebaudiana leaves.
Production of a bioactive sweetener steviolbioside via specific hydrolyzing ester linkage of stevioside with a beta-galactosidase.[Pubmed:26593477]
Food Chem. 2016 Apr 1;196:155-60.
A beta-galactosidase from Kluyveromyces lactis was found to specifically catalyze hydrolysis of the glycosyl ester linkage of stevioside to yield Steviolbioside, a rare sweetener that also exists in Stevia rebaudiana leaves. In a packed bed reactor, a reaction coupling separation was realized and a production yield of Steviolbioside reached 90% in 6 h. The hydrolysis product Steviolbioside presented higher cytoxicity on human normal cells (hepatocytes cell L02 and intestinal epithelial cell T84) than stevioside did. Comparing to the typical chemotherapy agent, 5-fluorouracil (5-FU), Steviolbioside presents much lower cytotoxicity on all assayed human normal cells; it presented notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3. The remarkable inhibition on MDA-MB-231 cells makes Steviolbioside a potential remedy for human breast cancer, when Steviolbioside is served as a natural sweetener.
