LipiferolideCAS# 41059-80-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 41059-80-7 | SDF | Download SDF |
| PubChem ID | 5281478 | Appearance | Powder |
| Formula | C17H22O5 | M.Wt | 306.4 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1=CCCC2(C(O2)C3C(C(C1)OC(=O)C)C(=C)C(=O)O3)C | ||
| Standard InChIKey | ODYJJNFWFYUXSS-CTSUEIOESA-N | ||
| Standard InChI | InChI=1S/C17H22O5/c1-9-6-5-7-17(4)15(22-17)14-13(10(2)16(19)21-14)12(8-9)20-11(3)18/h6,12-15H,2,5,7-8H2,1,3-4H3/b9-6+/t12-,13-,14+,15?,17-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells. 2. Liriodenine has antiplasmodial activity. 3. Lipiferolide and epitulipinolide diepoxide possess cytotoxic activity against KB cells. |
| Targets | Antifection |
Lipiferolide Dilution Calculator
Lipiferolide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2637 mL | 16.3185 mL | 32.6371 mL | 65.2742 mL | 81.5927 mL |
| 5 mM | 0.6527 mL | 3.2637 mL | 6.5274 mL | 13.0548 mL | 16.3185 mL |
| 10 mM | 0.3264 mL | 1.6319 mL | 3.2637 mL | 6.5274 mL | 8.1593 mL |
| 50 mM | 0.0653 mL | 0.3264 mL | 0.6527 mL | 1.3055 mL | 1.6319 mL |
| 100 mM | 0.0326 mL | 0.1632 mL | 0.3264 mL | 0.6527 mL | 0.8159 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Timosaponin A3
Catalog No.:BCN4999
CAS No.:41059-79-4
- Sirtinol
Catalog No.:BCC2224
CAS No.:410536-97-9
- Palovarotene
Catalog No.:BCC4185
CAS No.:410528-02-8
- H-D-Ala-OBzl.TosOH
Catalog No.:BCC2850
CAS No.:41036-32-2
- Desacetylcinobufotalin
Catalog No.:BCC8166
CAS No.:4099-30-3
- Medioresinol
Catalog No.:BCN5462
CAS No.:40957-99-1
- Glycitein
Catalog No.:BCN5896
CAS No.:40957-83-3
- Taxiresinol
Catalog No.:BCN4637
CAS No.:40951-69-7
- VU0152100
Catalog No.:BCC4053
CAS No.:409351-28-6
- JNJ 16259685
Catalog No.:BCC7332
CAS No.:409345-29-5
- 3,4-Dimethoxycinnamyl alcohol
Catalog No.:BCN6499
CAS No.:40918-90-9
- Sinoacutine
Catalog No.:BCN5461
CAS No.:4090-18-0
- Neobavaisoflavone
Catalog No.:BCN3194
CAS No.:41060-15-5
- Skullcapflavone I
Catalog No.:BCN5464
CAS No.:41060-16-6
- Steviolbioside
Catalog No.:BCN6800
CAS No.:41093-60-1
- Memantine hydrochloride
Catalog No.:BCC9018
CAS No.:41100-52-1
- Platyphyllonol
Catalog No.:BCN5465
CAS No.:41137-85-3
- Hirsutanonol
Catalog No.:BCN5466
CAS No.:41137-86-4
- Hirsutenone
Catalog No.:BCN5467
CAS No.:41137-87-5
- Boc-Phe(4-F)-OH
Catalog No.:BCC3219
CAS No.:41153-30-4
- CMPD-1
Catalog No.:BCC7274
CAS No.:41179-33-3
- erythro-Guaiacylglycerol beta-sinapyl ether 7-O-glucoside
Catalog No.:BCN7348
CAS No.:412029-03-9
- Pseudolarolide F
Catalog No.:BCN6428
CAS No.:412321-91-6
- H-Asp-OtBu
Catalog No.:BCC2883
CAS No.:4125-93-3
Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.[Pubmed:20826204]
J Ethnopharmacol. 2011 Jan 7;133(1):26-30.
AIM OF THE STUDY: The objective of this study was to isolate and characterize the active constituents of the traditionally used antimalarial plant Liriodendron tulipifera by antiplasmodial-assay guided fractionation. MATERIALS AND METHODS: Bark and leaves were extracted with solvents of increasing polarity. Fractions were generated using flash chromatography, counter current chromatography and preparative HPLC and subjected to in vitro antiplasmodial and cytotoxicity assays. Active fractions were subjected to further fractionation until pure compounds were isolated, for which the IC(50) values were calculated. RESULTS AND DISCUSSION: Six known aporphine alkaloids, asimilobine (1), norushinsunine (2), norglaucine (3), liriodenine (4), anonaine (5) and oxoglaucine (6) were found to be responsible for the antiplasmodial activity of the bark. Leaves yielded two known sesquiterpene lactones, peroxyferolide (7) and Lipiferolide (8) with antiplasmodial activity. The antiplasmodial activity of (2) (IC(50)=29.6 mug/mL), (3) (IC(50)=22.0 mug/mL), (6) (IC(50)=9.1 mug/mL), (7) (IC(50)=6.2 mug/mL) and (8) (IC(50)=1.8 mug/mL) are reported for the first time. CONCLUSION: This work supports the historical use of Liriodendron tulipifera as an antimalarial remedy of the United States and characterizes its antiplasmodial constituents.
Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera.[Pubmed:17424934]
Arch Pharm Res. 2007 Mar;30(3):299-302.
The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of Lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
