SR-9243inverse agonist of LXR CAS# 1613028-81-1 |
Related Products
- T0901317
Catalog No.:BCC1178
CAS No.:293754-55-9
- GW3965
Catalog No.:BCC1612
CAS No.:405911-09-3
- GW3965 HCl
Catalog No.:BCC3790
CAS No.:405911-17-3
- Fexaramine
Catalog No.:BCC7412
CAS No.:574013-66-4
- LXR-623
Catalog No.:BCC4273
CAS No.:875787-07-8
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1613028-81-1 | SDF | Download SDF |
| PubChem ID | 76073169 | Appearance | Powder |
| Formula | C31H32BrNO4S2 | M.Wt | 626.62 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 20 mg/mL (31.92 mM; Need ultrasonic) | ||
| Chemical Name | N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[4-(3-methylsulfonylphenyl)phenyl]methyl]benzenesulfonamide | ||
| SMILES | CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CCC2=CC(=CC=C2)Br)CC3=CC=C(C=C3)C4=CC(=CC=C4)S(=O)(=O)C)C | ||
| Standard InChIKey | FYQFEJFTCLKXTQ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C31H32BrNO4S2/c1-22-17-23(2)31(24(3)18-22)39(36,37)33(16-15-25-7-5-9-29(32)19-25)21-26-11-13-27(14-12-26)28-8-6-10-30(20-28)38(4,34)35/h5-14,17-20H,15-16,21H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice. |
SR-9243 Dilution Calculator
SR-9243 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5959 mL | 7.9793 mL | 15.9586 mL | 31.9173 mL | 39.8966 mL |
| 5 mM | 0.3192 mL | 1.5959 mL | 3.1917 mL | 6.3835 mL | 7.9793 mL |
| 10 mM | 0.1596 mL | 0.7979 mL | 1.5959 mL | 3.1917 mL | 3.9897 mL |
| 50 mM | 0.0319 mL | 0.1596 mL | 0.3192 mL | 0.6383 mL | 0.7979 mL |
| 100 mM | 0.016 mL | 0.0798 mL | 0.1596 mL | 0.3192 mL | 0.399 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction. It potently reduces cancer cell viability (IC50=15–104 nM) in MTT reduction assays in prostate (PC3 and DU-145), colorectal (SW620 and HT29), and lung (HOP-62 and NCI-H23) cancer cell lines. [1]
LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors. It is an important regulator of glycolysis and lipogenesis enzyme expression.
In SW620 cells, 1 mM SR9243 treatment for 12 hours induces cell death with a robust increase in caspase 3/7 activation. In addition, SR9243 disrupts the Warburg effect, suppresses lipogenesis gene expression and lipid production in cancer cells without effecting normal cells. [1]
In colon tumor xenograft, SR9243 substantially and dose-dependently reduces tumor growth, glycolytic (GCK1, PFK2, PFK1 and LDH) and lipogenic (SCD1, FASN, and SREBP1c) enzyme expression without promoting weight loss. SR9243 also blocks tumor growth without causing immune or hepatic toxicity in vivo. [1]
Reference:
1. Flaveny CA, Griffett K, El-Gendy Bel-D et al. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell. 2015 Jul 13;28(1):42-56.
Featured Products
- H-Orn(Z)-OtBu.HCl
Catalog No.:BCC2677
CAS No.:161234-80-6
- Cimicidanol 3-O-alpha-L-arabinoside
Catalog No.:BCN6528
CAS No.:161207-05-2
- H-Asp(OEt)-OEt.HCl
Catalog No.:BCC2888
CAS No.:16115-68-7
- Bidwillol A
Catalog No.:BCN4858
CAS No.:161099-42-9
- Cimicifugoside H2
Catalog No.:BCN7949
CAS No.:161097-77-4
- Formyl-DL-Trp-OH
Catalog No.:BCC3120
CAS No.:16108-03-5
- Epimedokoreanin C
Catalog No.:BCN8080
CAS No.:161068-54-8
- Epimedokoreanin B
Catalog No.:BCN6483
CAS No.:161068-53-7
- VT-464
Catalog No.:BCC5398
CAS No.:1610537-15-9
- Hosenkoside M
Catalog No.:BCN4518
CAS No.:161016-51-9
- Dihydroperaksine
Catalog No.:BCN1713
CAS No.:16100-84-8
- TH588
Catalog No.:BCC6397
CAS No.:1609960-31-7
New Products
- 1-O-Acetyl-6-O-isobutyrylbritannilactone
Catalog No.:BCN7795
CAS No.:1613152-34-3
- Fmoc-Chg-OH
Catalog No.:BCC3164
CAS No.:161321-36-4
- SGC-CBP30
Catalog No.:BCC2419
CAS No.:1613695-14-9
- HTH-01-015
Catalog No.:BCC4010
CAS No.:1613724-42-7
- ABT
Catalog No.:BCC7998
CAS No.:1614-12-6
- SIN-1 chloride
Catalog No.:BCC5670
CAS No.:16142-27-1
- 7-NINA
Catalog No.:BCC5674
CAS No.:161467-34-1
- 4-Chlorocinnamic acid
Catalog No.:BCN5032
CAS No.:1615-02-7
- Simiarenol
Catalog No.:BCN1714
CAS No.:1615-94-7
- Fmoc-Alaninol
Catalog No.:BCC2729
CAS No.:161529-13-1
- Cyclo (-RGDfK)
Catalog No.:BCC3590
CAS No.:161552-03-0
- Ro 48-8071
Catalog No.:BCC5545
CAS No.:161582-11-2
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.
SR-9243,1613028-81-1,Natural Products,LXR, buy SR-9243 , SR-9243 supplier , purchase SR-9243 , SR-9243 cost , SR-9243 manufacturer , order SR-9243 , high purity SR-9243
