Prosapogenin ACAS# 19057-67-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 19057-67-1 | SDF | Download SDF |
| PubChem ID | 11061578 | Appearance | White powder |
| Formula | C39H62O12 | M.Wt | 722.9 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Synonyms | Lilioglycoside D; Ophiopogonin C'; Polyphyllin V; Progenin III; Prosapogenin D'1 | ||
| Solubility | Soluble in methan | ||
| SMILES | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)C)OC1 | ||
| Standard InChIKey | HDXIQHTUNGFJIC-FOAHKCLGSA-N | ||
| Standard InChI | InChI=1S/C39H62O12/c1-18-8-13-39(46-17-18)19(2)28-26(51-39)15-25-23-7-6-21-14-22(9-11-37(21,4)24(23)10-12-38(25,28)5)48-36-34(32(44)30(42)27(16-40)49-36)50-35-33(45)31(43)29(41)20(3)47-35/h6,18-20,22-36,40-45H,7-17H2,1-5H3/t18-,19+,20+,22+,23-,24+,25+,26+,27-,28+,29+,30-,31-,32+,33-,34-,35+,36-,37+,38+,39-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Prosapogenin A has anti-obesity, and immunomodulating effects, it exhibits cytotoxic activity against the cancer cell line K562 in vitro. |
| Targets | STAT | GLUT |
| In vitro | Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.[Pubmed: 24179517]Oncol Lett. 2013 Nov;6(5):1323-1328.Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality. |
| Kinase Assay | Prosapogenin A inhibits cell growth of MCF7 via downregulating STAT3 and glycometabolism-related gene.[Pubmed: 24358789]Yao Xue Xue Bao. 2013 Sep;48(9):1510-4.This study is to investigate the inhibitory effect and mechanism of Prosapogenin A (PSA) on MCF7. |
Prosapogenin A Dilution Calculator
Prosapogenin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3833 mL | 6.9166 mL | 13.8332 mL | 27.6663 mL | 34.5829 mL |
| 5 mM | 0.2767 mL | 1.3833 mL | 2.7666 mL | 5.5333 mL | 6.9166 mL |
| 10 mM | 0.1383 mL | 0.6917 mL | 1.3833 mL | 2.7666 mL | 3.4583 mL |
| 50 mM | 0.0277 mL | 0.1383 mL | 0.2767 mL | 0.5533 mL | 0.6917 mL |
| 100 mM | 0.0138 mL | 0.0692 mL | 0.1383 mL | 0.2767 mL | 0.3458 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.[Pubmed:24179517]
Oncol Lett. 2013 Nov;6(5):1323-1328.
Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality. In the present study, the effects of Prosapogenin A (PSA) from the traditional Chinese medicine, Veratrum, on apoptosis, the STAT3 signaling pathway and glycometabolism in cancer cells were investigated. The results indicated that PSA induced growth inhibition and apoptosis in HeLa, HepG2 and MCF-7 cells. PSA inhibited the STAT3 signaling pathway and modulated the expression of glycometabolism-related genes. The results indicate that the inhibition of the STAT3 signaling and glycometabolism pathways contributes to the PSA-mediated apoptosis of HeLa, HepG2 and MCF-7 cells.
[Prosapogenin A inhibits cell growth of MCF7 via downregulating STAT3 and glycometabolism-related gene].[Pubmed:24358789]
Yao Xue Xue Bao. 2013 Sep;48(9):1510-4.
This study is to investigate the inhibitory effect and mechanism of Prosapogenin A (PSA) on MCF7. MTT assay was performed to determine the inhibitory effect of PSA on MCF7 cells. PI/Hoechst 33342 double staining was used to detect cell apoptosis. RT-PCR was used to test the mRNA levels of STAT3, GLUT1, HK and PFKL. Western blotting was performed to determine the expression of STAT3 and pSTAT3 protein in MCF7 cells. The results showed that PSA could dose-dependently inhibit cell growth of MCF7 followed by IC50 of 9.65 micrmol x L(-1) and promote cell apoptosis of MCF7. Reduced mRNA levels of STAT3, HK and PFKL were observed in MCF7 cells treated with 5 micromol x L(-1) of PSA. PSA also decreased the level of pSTAT3 protein. STAT3 siRNA caused decrease of mRNA of GLUT1, HK and PFKL which indicated STAT3 could regulate the expressions of GLUT1, HK and PFKL. The results suggested that PSA could inhibit cell growth and promote cell apoptosis of MCF7 via inhibition of STAT3 and glycometabolism-related gene.
