Ophiopogonin D'CAS# 65604-80-0 |
- Liriope muscari baily saponins C
Catalog No.:BCN2340
CAS No.:87480-46-4
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 65604-80-0 | SDF | Download SDF |
| PubChem ID | 10033524 | Appearance | Powder |
| Formula | C44H70O16 | M.Wt | 855.02 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)OC8C(C(C(CO8)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)OC1 | ||
| Standard InChIKey | DQYACEDUQHWXQZ-QOYNBSPSSA-N | ||
| Standard InChI | InChI=1S/C44H70O16/c1-19-8-13-44(54-17-19)20(2)30-28(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)56-41-38(59-40-36(52)34(50)31(47)21(3)55-40)37(33(49)29(16-45)57-41)58-39-35(51)32(48)27(46)18-53-39/h6,19-21,23-41,45-52H,7-18H2,1-5H3/t19-,20+,21+,23+,24-,25+,26+,27-,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39+,40+,41-,42+,43+,44-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10. |
| Targets | SIRT1 | UGT1A6 | UGT1A10 |
| In vitro | The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.[Pubmed: 25530784]Evid Based Complement Alternat Med. 2014;2014:594354.The mechanism of shengmai injection- (SMI-) related drug-drug interaction remains unclear. Evaluation of the inhibition potential of SMI's ingredients towards UDP-glucuronosyltransferases (UGTs) activity will provide a new insight to understand SMI-related drug-drug interaction.
|
| Structure Identification | Anal Chem. 2015 May 19;87(10):5046-9.Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging.[Pubmed: 25903518]SIRT1 is an important protein that catalyzes the nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylation reaction, which is regarded as a novel target to treat metabolic disorders and aging-related diseases. However, there is lack of appropriate approach for SIRT1 modulator screening and bioimaging of SIRT1 in living cells. |
Ophiopogonin D' Dilution Calculator
Ophiopogonin D' Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.1696 mL | 5.8478 mL | 11.6956 mL | 23.3913 mL | 29.2391 mL |
| 5 mM | 0.2339 mL | 1.1696 mL | 2.3391 mL | 4.6783 mL | 5.8478 mL |
| 10 mM | 0.117 mL | 0.5848 mL | 1.1696 mL | 2.3391 mL | 2.9239 mL |
| 50 mM | 0.0234 mL | 0.117 mL | 0.2339 mL | 0.4678 mL | 0.5848 mL |
| 100 mM | 0.0117 mL | 0.0585 mL | 0.117 mL | 0.2339 mL | 0.2924 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Cerberic acid
Catalog No.:BCN4200
CAS No.:65597-44-6
- Cerbinal
Catalog No.:BCN4199
CAS No.:65597-42-4
- 4'-Demethylepipodophyllotoxin
Catalog No.:BCN5918
CAS No.:6559-91-7
- 1-Hydroxyacridone
Catalog No.:BCN7524
CAS No.:65582-54-9
- Europine N-oxide
Catalog No.:BCN1977
CAS No.:65582-53-8
- Cyclo(Pro-Ala)
Catalog No.:BCN2427
CAS No.:65556-33-4
- Esculentoside A
Catalog No.:BCN5010
CAS No.:65497-07-6
- Naftifine HCl
Catalog No.:BCC4806
CAS No.:65473-14-5
- (Z)-23-Coumaroylhederagenin
Catalog No.:BCN3748
CAS No.:654678-61-2
- Sitagliptin phosphate
Catalog No.:BCC9148
CAS No.:654671-78-0
- Sitagliptin phosphate monohydrate
Catalog No.:BCC2111
CAS No.:654671-77-9
- Fmoc-Asn(Trt)-ol
Catalog No.:BCC2585
CAS No.:654670-89-0
- Nintedanib (BIBF 1120)
Catalog No.:BCC3661
CAS No.:656247-17-5
- Fenretinide
Catalog No.:BCC1572
CAS No.:65646-68-6
- Esculentoside E
Catalog No.:BCN5014
CAS No.:65649-36-7
- Silybin B maltoside
Catalog No.:BCC8250
CAS No.:335299-49-5
- HA14-1
Catalog No.:BCC3593
CAS No.:65673-63-4
- AG-1024
Catalog No.:BCC1242
CAS No.:65678-07-1
- TC-C 14G
Catalog No.:BCC6144
CAS No.:656804-72-7
- Reversine
Catalog No.:BCC1892
CAS No.:656820-32-5
- Metformin
Catalog No.:BCC9026
CAS No.:657-24-9
- H-Lys-OH.2HCl
Catalog No.:BCC2979
CAS No.:657-26-1
- H-Lys-OH.HCl
Catalog No.:BCC2978
CAS No.:657-27-2
- Z-D-Glu-OBzl
Catalog No.:BCC2774
CAS No.:65706-99-2
Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging.[Pubmed:25903518]
Anal Chem. 2015;87(10):5046-9.
SIRT1 is an important protein that catalyzes the nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylation reaction, which is regarded as a novel target to treat metabolic disorders and aging-related diseases. However, there is lack of appropriate approach for SIRT1 modulator screening and bioimaging of SIRT1 in living cells. We designed and synthesized a "turn-on" fluorescent probe by connecting a specifically recognized peptide to tetraphenylethene core. It exhibits excellent selectivity and sensitivity in homogeneous measurement of SIRT1 activity for screening both SIRT1 inhibitors and activators. 20(S)-ginsenoside Rg3 and ophiopogonin D' were found to activate SIRT1. It was also successfully applied to monitor SIRT1 modulation in the cardiomyocytes as well as in the wild-type and SIRT1(-/-) mesenchymal stem cells.
The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.[Pubmed:25530784]
Evid Based Complement Alternat Med. 2014;2014:594354.
The mechanism of shengmai injection- (SMI-) related drug-drug interaction remains unclear. Evaluation of the inhibition potential of SMI's ingredients towards UDP-glucuronosyltransferases (UGTs) activity will provide a new insight to understand SMI-related drug-drug interaction. In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 muM, respectively. In combination with our previous results obtained for the inhibition of UGT isoforms by ginsenosides and wuweizi components, the important SMI ingredients exhibiting strong inhibition towards UGT isoforms were highlighted. All the results obtained in the present study provide a new insight to understand SMI-related drug-drug interaction.
