Notoginsenoside FcCAS# 88122-52-5 |
| Cas No. | 88122-52-5 | SDF | File under preparation. |
| PubChem ID | 75412556 | Appearance | Powder |
| Formula | C58H98O26 | M.Wt | 1211.4 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3R,4S,5S,6R)-2-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol | ||
| SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)OC7C(C(C(CO7)O)O)O)C)C)O)C)OC8C(C(C(C(O8)COC9C(C(C(CO9)O)O)O)O)O)O)C | ||
| Standard InChIKey | XBGLCVZQMWKHFC-NMQALWILSA-N | ||
| Standard InChI | InChI=1S/C58H98O26/c1-24(2)10-9-14-58(8,84-51-46(74)41(69)40(68)31(80-51)23-77-49-44(72)36(64)27(62)21-75-49)25-11-16-57(7)35(25)26(61)18-33-55(5)15-13-34(54(3,4)32(55)12-17-56(33,57)6)81-52-47(42(70)38(66)29(19-59)78-52)83-53-48(43(71)39(67)30(20-60)79-53)82-50-45(73)37(65)28(63)22-76-50/h10,25-53,59-74H,9,11-23H2,1-8H3/t25-,26+,27+,28+,29+,30+,31+,32-,33+,34-,35-,36-,37-,38+,39+,40+,41-,42-,43-,44+,45+,46+,47+,48+,49-,50-,51-,52-,53-,55-,56+,57+,58-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Description | Notoginsenoside Fc has perfect anti-platelet aggregatory effect. |
| Targets | PAFR |
| In vivo | Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]J Pharm Biomed Anal. 2015 May 10;109:150-7.Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown. |
| Structure Identification | Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl.Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue).[Pubmed: 1294178]Six saponins were isolated from the fruit pedicels of Panax notoginseng. |
Notoginsenoside Fc Dilution Calculator
Notoginsenoside Fc Molarity Calculator
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Notoginsenoside SCatalog No.: BCN8371CAS No.: 575446-95-6 -
Notoginsenoside DCatalog No.: BCX1024CAS No.: 193895-50-0 -
Ginsenoside Rb2Catalog No.: BCN1064CAS No.: 11021-13-9 -
Notoginsenoside FaCatalog No.: BCN3854CAS No.: 88100-04-3 -
Notoginsenoside FP2Catalog No.: BCN8692CAS No.: 1004988-75-3 -
Notoginsenoside R4Catalog No.: BCN8834CAS No.: 87741-77-3 -
Ginsenoside Ra2Catalog No.: BCN8555CAS No.: 83459-42-1 -
Ginsenoside Ra1Catalog No.: BCN8392CAS No.: 83459-41-0 -
Ginsenoside Ra3Catalog No.: BCN0860CAS No.: 90985-77-6 -
Vinaginsenoside R7Catalog No.: BCX1594CAS No.: 156009-83-5 -
StevenleafCatalog No.: BCN5978CAS No.: 80321-63-7 -
Ginsenoside Rd2Catalog No.: BCN8279CAS No.: 83480-64-2 -
Ginsenoside Rs1Catalog No.: BCX1097CAS No.: 87733-67-3 -
Ginsenoside Rb1Catalog No.: BCN1063CAS No.: 41753-43-9 -
Ginsenoside RcCatalog No.: BCN1072CAS No.: 11021-14-0 -
Gypenoside XVIICatalog No.: BCN2339CAS No.: 80321-69-3 -
Notoginsenoside FeCatalog No.: BCN3852CAS No.: 88105-29-7 -
Quinquenoside R1Catalog No.: BCX0684CAS No.: 85013-02-1 -
Ginsenoside Rs2Catalog No.: BCX2528CAS No.: 87733-66-2 -
Pseudoginsenoside RC1Catalog No.: BCX1331CAS No.: 102805-32-3 -
Notoginsenoside Ft1Catalog No.: BCN6434CAS No.: 155683-00-4 -
Ginsenoside F2Catalog No.: BCN1245CAS No.: 62025-49-4 -
Malonylginsenoside Rb(1)Catalog No.: BCC9230CAS No.: 88140-34-5 -
Gypenoside XIIICatalog No.: BCN8927CAS No.: 80325-22-0 -
Ginsenoside CYCatalog No.: BCX1492CAS No.: 83480-65-3 -
Gypenoside LXXVCatalog No.: BCX0478CAS No.: 110261-98-8 -
20(R)-Ginsenoside Rg3Catalog No.: BCN5018CAS No.: 38243-03-7 -
Ginsenoside Rg3Catalog No.: BCN1068CAS No.: 14197-60-5 -
Ginsenoside Rb3Catalog No.: BCN1065CAS No.: 68406-26-8 -
Vinaginsenoside R4Catalog No.: BCN8659CAS No.: 156009-80-2 -
Notoginsenoside R1Catalog No.: BCN1097CAS No.: 80418-24-2 -
Vinaginsenoside R3Catalog No.: BCN8550CAS No.: 156012-92-9
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.8255 mL | 4.1275 mL | 8.2549 mL | 16.5098 mL | 20.6373 mL |
| 5 mM | 0.1651 mL | 0.8255 mL | 1.651 mL | 3.302 mL | 4.1275 mL |
| 10 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 1.651 mL | 2.0637 mL |
| 50 mM | 0.0165 mL | 0.0825 mL | 0.1651 mL | 0.3302 mL | 0.4127 mL |
| 100 mM | 0.0083 mL | 0.0413 mL | 0.0825 mL | 0.1651 mL | 0.2064 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed:25770412]
J Pharm Biomed Anal. 2015 May 10;109:150-7.
Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown. In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56-->m/z 783.90 and m/z 799.93-->m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002mug/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits. The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.
[Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue)].[Pubmed:1294178]
Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl..
Six saponins were isolated from the fruit pedicels of Panax notoginseng. Five of them were identified as gypenoside-XVII, -XV, ginsenoside-Rb1, and notoginsenoside-Fc, -Fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards. Quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry.
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