NorwogoninCAS# 4443-09-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 4443-09-8 | SDF | Download SDF |
| PubChem ID | 5281674 | Appearance | Yellow powder |
| Formula | C15H10O5 | M.Wt | 270.2 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,7,8-trihydroxy-2-phenylchromen-4-one | ||
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O | ||
| Standard InChIKey | ZFKKRRMUPBBYRS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR. |
| Targets | VHR |
| Kinase Assay | Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]Planta Med. 2002 Dec;68(12):1063-5.Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). |
Norwogonin Dilution Calculator
Norwogonin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.701 mL | 18.5048 mL | 37.0096 mL | 74.0192 mL | 92.5241 mL |
| 5 mM | 0.7402 mL | 3.701 mL | 7.4019 mL | 14.8038 mL | 18.5048 mL |
| 10 mM | 0.3701 mL | 1.8505 mL | 3.701 mL | 7.4019 mL | 9.2524 mL |
| 50 mM | 0.074 mL | 0.3701 mL | 0.7402 mL | 1.4804 mL | 1.8505 mL |
| 100 mM | 0.037 mL | 0.185 mL | 0.3701 mL | 0.7402 mL | 0.9252 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed:12494330]
Planta Med. 2002 Dec;68(12):1063-5.
Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC 50 = 1.1 microM), dihydroNorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.
