Beta-TocotrienolCAS# 490-23-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 490-23-3 | SDF | Download SDF |
| PubChem ID | 5282348 | Appearance | Powder |
| Formula | C28H42O2 | M.Wt | 410.6 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R)-2,5,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol | ||
| SMILES | CC1=CC(=C(C2=C1OC(CC2)(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)O | ||
| Standard InChIKey | FGYKUFVNYVMTAM-WAZJVIJMSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. 2. Beta-Tocotrienol inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. |
| Targets | Caspase |
Beta-Tocotrienol Dilution Calculator
Beta-Tocotrienol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4355 mL | 12.1773 mL | 24.3546 mL | 48.7092 mL | 60.8865 mL |
| 5 mM | 0.4871 mL | 2.4355 mL | 4.8709 mL | 9.7418 mL | 12.1773 mL |
| 10 mM | 0.2435 mL | 1.2177 mL | 2.4355 mL | 4.8709 mL | 6.0887 mL |
| 50 mM | 0.0487 mL | 0.2435 mL | 0.4871 mL | 0.9742 mL | 1.2177 mL |
| 100 mM | 0.0244 mL | 0.1218 mL | 0.2435 mL | 0.4871 mL | 0.6089 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by beta-tocotrienol in human lung and brain cancer cell lines.[Pubmed:25456851]
Biomed Pharmacother. 2014 Oct;68(8):1105-15.
The pure vitamin isomer, Beta-Tocotrienol has the least abundance among the other vitamin E isomers that are present in numerous plants. Hence, it is very scarcely studied for its bioactivity. In this study, the antiproliferative effects and primary apoptotic mechanisms of Beta-Tocotrienol on human lung adenocarcinoma A549 and glioblastoma U87MG cells were investigated. It was evidenced that Beta-Tocotrienol had inhibited the growth of both A549 (GI50=1.38+/-0.334muM) and U87MG (GI50=2.53+/-0.604muM) cells at rather low concentrations. Cancer cells incubated with Beta-Tocotrienol were also found to exhibit hallmarks of apoptotic morphologies including membrane blebbing, chromatin condensation and formation of apoptotic bodies. The apoptotic properties of Beta-Tocotrienol in both A549 and U87MG cells were the results of its capability to induce significant (P<0.05) double-strand DNA breaks (DSBs) without involving single-strand DNA breaks (SSBs). Beta-Tocotrienol is said to induce activation of caspase-8 in both A549 and U87MG cells guided by no activation when caspase-8 inhibitor, z-IETD-fmk was added. Besides, disruption on the mitochondrial membrane permeability of the cells in a concentration- and time-dependent manner had occurred. The induction of apoptosis by Beta-Tocotrienol in A549 and U87MG cells was confirmed to involve both the death-receptor mediated and mitochondria-dependent apoptotic pathways. These findings could potentiate the palm oil derived Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers.
