Linoleic acidCAS# 60-33-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 60-33-3 | SDF | Download SDF |
| PubChem ID | 5280450 | Appearance | Oil |
| Formula | C18H32O2 | M.Wt | 280.5 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 43.33 mg/mL (154.50 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (9Z,12Z)-octadeca-9,12-dienoic acid | ||
| SMILES | CCCCCC=CCC=CCCCCCCCC(=O)O | ||
| Standard InChIKey | OYHQOLUKZRVURQ-HZJYTTRNSA-N | ||
| Standard InChI | InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Essential fatty acid. Prostaglandin precursor. |
Linoleic acid Dilution Calculator
Linoleic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5651 mL | 17.8253 mL | 35.6506 mL | 71.3012 mL | 89.1266 mL |
| 5 mM | 0.713 mL | 3.5651 mL | 7.1301 mL | 14.2602 mL | 17.8253 mL |
| 10 mM | 0.3565 mL | 1.7825 mL | 3.5651 mL | 7.1301 mL | 8.9127 mL |
| 50 mM | 0.0713 mL | 0.3565 mL | 0.713 mL | 1.426 mL | 1.7825 mL |
| 100 mM | 0.0357 mL | 0.1783 mL | 0.3565 mL | 0.713 mL | 0.8913 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Studies on the effect of a nutritious vegetable, Telfairia occidentalis, on HbSS blood.[Pubmed:30963050]
J Tradit Complement Med. 2018 Jul 6;9(2):156-162.
Medicinal plants have been used traditionally in Africa, especially Nigeria, in the management of sickle cell disorder (SCD) whose treatment has been mainly palliative. The antisickling properties of ethanol extract of Telfairia occidentalis Hook, F. (TO) (Family Cucurbitaceae) leaf was tested in vitro at concentrations 1, 2, 4, 8 and 16 mg/mL using inhibitory and reversal models. Nitrogen gas was used to induce hypoxia for 1 h. The effect of TO on red cell density and cell membrane were also determined. The methanol sub fraction of TO extract was subjected to GC/MS to identify some of the active compounds. The TO gave antisickling activities of 78.84 +/- 1.34% inhibition and 95.4 +/- 0.81% reversal, which are significantly (p < 0.05) higher than that of Ciklavit((R)). The TO extract gave a change in density of 17.83 +/- 0.77% and a dose dependent activity on RBC membrane. Methyl 9-cis 11- trans-octadecadienoate; 1, 4- benzenedicarboxylic acid; 9, 12-octadecadienoic acid (Linoleic acid); and hexadecanoic acid methyl ester (palmitic acid); were identified from TO ethanol leaf extract for the first time using GC/MS. This study authenticated the ethnomedicinal claims of the use of T. occidentalis in the management of sickle cell disorder.
Linoleic acid rescues microglia inflammation triggered by saturated fatty acid.[Pubmed:30952426]
Biochem Biophys Res Commun. 2019 Apr 2. pii: S0006-291X(19)30424-3.
Elevated saturated free fatty acid levels during over-nutrition lead to hypothalamic inflammation, which perturbs energy homeostasis. Whether brain-derived metabolites are coupled to the development of obesity pathogenesis during the early over-nutrition period has not been thoroughly investigated. In this study, we found increased Linoleic acid, an unsaturated fatty acid, in both the whole brain and hypothalamus of mice fed a high-fat diet for 4 weeks. Furthermore, we observed that Linoleic acid effectively reversed the inflammatory responses induced by palmitic acid treatment in microglial cells. Collectively, this study suggests the reversible function of Linoleic acid on brain inflammation in association with microglial activation during short-term exposure to a high-fat diet.
