IsotetrandrineCAS# 477-57-6 |
- Tetrandrine
Catalog No.:BCN5955
CAS No.:518-34-3
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 477-57-6 | SDF | Download SDF |
| PubChem ID | 457825 | Appearance | Powder |
| Formula | C38H42N2O6 | M.Wt | 622.8 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | (R,S)-Tetrandrine;Isosinomenine A;O,O'-Dimethylstepholine | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC | ||
| Standard InChIKey | WVTKBKWTSCPRNU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. 2. Isotetrandrine dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process. |
| Targets | IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK |
Isotetrandrine Dilution Calculator
Isotetrandrine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6057 mL | 8.0283 mL | 16.0565 mL | 32.113 mL | 40.1413 mL |
| 5 mM | 0.3211 mL | 1.6057 mL | 3.2113 mL | 6.4226 mL | 8.0283 mL |
| 10 mM | 0.1606 mL | 0.8028 mL | 1.6057 mL | 3.2113 mL | 4.0141 mL |
| 50 mM | 0.0321 mL | 0.1606 mL | 0.3211 mL | 0.6423 mL | 0.8028 mL |
| 100 mM | 0.0161 mL | 0.0803 mL | 0.1606 mL | 0.3211 mL | 0.4014 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Podophyllotoxinone
Catalog No.:BCN8063
CAS No.:477-49-6
- Beta-Apopicropodophyllin
Catalog No.:BCC1388
CAS No.:477-52-1
- Dehydrocostus lactone
Catalog No.:BCN5536
CAS No.:477-43-0
- Samidin
Catalog No.:BCN6665
CAS No.:477-33-8
- Demecolcine
Catalog No.:BCC9223
CAS No.:477-30-5
- Lycorenine
Catalog No.:BCN2507
CAS No.:477-19-0
- Boc-Tyr(2-Br-Z)-OH
Catalog No.:BCC3460
CAS No.:47689-67-8
- 3-(2-Benzothiazolylthio)propionic acid
Catalog No.:BCC8586
CAS No.:4767-00-4
- 6,9,10-Trihydroxy-7-megastigmen-3-one
Catalog No.:BCN1435
CAS No.:476682-97-0
- Lushanrubescensin H
Catalog No.:BCN3235
CAS No.:476640-22-9
- Eupaglehnin C
Catalog No.:BCN7118
CAS No.:476630-49-6
- VO-Ohpic trihydrate
Catalog No.:BCC2043
CAS No.:476310-60-8
- Isochondodendrine
Catalog No.:BCC9234
CAS No.:477-62-3
- Damnacanthal
Catalog No.:BCN5539
CAS No.:477-84-9
- Obtusifolin
Catalog No.:BCN2537
CAS No.:477-85-0
- Digitolutein
Catalog No.:BCN3089
CAS No.:477-86-1
- Bergenin
Catalog No.:BCN5540
CAS No.:477-90-7
- Mangiferin
Catalog No.:BCN5535
CAS No.:4773-96-0
- (±)-AC 7954 hydrochloride
Catalog No.:BCC7381
CAS No.:477313-09-0
- cis-ACPD
Catalog No.:BCC6566
CAS No.:477331-06-9
- Ophiopogonanone C
Catalog No.:BCN6620
CAS No.:477336-75-7
- Sculponeatin K
Catalog No.:BCN5537
CAS No.:477529-70-7
- Musellarin A
Catalog No.:BCN7186
CAS No.:477565-36-9
- PHA-665752
Catalog No.:BCC1181
CAS No.:477575-56-7
Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B.[Pubmed:24331940]
J Surg Res. 2014 Apr;187(2):596-604.
BACKGROUND: Mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappaB) signaling pathways are pleiotropic regulator of many genes involved in lipopolysaccharide (LPS)-induced acute lung injury (ALI). The present study aimed to reveal the protective effect of Isotetrandrine (ITD), a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. METHODS: In vitro, RAW 264.7 cells were pretreated with different dose of ITD 1 h before treatment with 1 mg/L of LPS. In vivo, to induce ALI, male BALB/c mice were injected intranasally with LPS and treated with ITD (20 and 40 mg/kg) 1 h before LPS. RESULTS: In vitro, the cytokine levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in supernatant were reduced by ITD. Meanwhile, in vivo, pulmonary inflammatory cell infiltration, myeloperoxidase activity, total cells, neutrophils, macrophages, along with the levels of tumor necrosis factor-alpha, IL-1beta, and IL-6 in bronchoalveolar lavage fluid were dose-dependently attenuated by ITD. Furthermore, our data showed that ITD significantly inhibited the activation of MAPK and NF-kappaB, which are induced by LPS in ALI model. CONCLUSIONS: These results suggested that ITD dose-dependently suppressed the severity of LPS-induced ALI by inactivation of MAPK and NF-kappaB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
