Higenamine 4'-O-beta-D-glucosideCAS# 1440545-91-4 |
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Number of papers citing our products
| Cas No. | 1440545-91-4 | SDF | File under preparation. |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C22H27NO8 | M.Wt | 433.5 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Higenamine 4'-O-beta-D-glucoside Dilution Calculator
Higenamine 4'-O-beta-D-glucoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3068 mL | 11.534 mL | 23.0681 mL | 46.1361 mL | 57.6701 mL |
| 5 mM | 0.4614 mL | 2.3068 mL | 4.6136 mL | 9.2272 mL | 11.534 mL |
| 10 mM | 0.2307 mL | 1.1534 mL | 2.3068 mL | 4.6136 mL | 5.767 mL |
| 50 mM | 0.0461 mL | 0.2307 mL | 0.4614 mL | 0.9227 mL | 1.1534 mL |
| 100 mM | 0.0231 mL | 0.1153 mL | 0.2307 mL | 0.4614 mL | 0.5767 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and Detailed Examination of Spectral Properties of (S) and (R)-Higenamine 4'-O-beta-d-Glucoside and HPLC Analytical Conditions to Distinguish the Diastereomers.[Pubmed:28858255]
Molecules. 2017 Aug 31;22(9):1450.
Higenamine is a tetrahydroisoquinoline present in several plants that has beta-adrenergic receptor agonist activity. Study of the biosynthesis of higenamine has shown the participation of norcoclaurine synthase, which controls the stereochemistry to construct the (S)-isomer. However, when isolated from nature, higenamine is found as the racemate, or even the (R)-isomer. We recently reported the isolation of higenamine 4'-O-beta-d-glucoside. Herein, its (R)- and (S)-isomers were synthesized and compared to precisely determine the stereochemistry of the isolate. Owing to their similar spectral properties, determination of the stereochemistry based on NMR data was considered inappropriate. Therefore, a high-performance liquid chromatography method was established to separate the isomers, and natural higenamine 4'-O-beta-d-glucoside was determined to be a mixture of isomers.
Higenamine 4'-O-beta-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through beta2-adrenergic receptor.[Pubmed:25943853]
Bioorg Med Chem. 2015 Jul 1;23(13):3317-21.
Hypoglycemic effect is an efficient means to modulate elevated blood glucose levels in patients with diabetes. We found that the extract of lotus plumule (the germ of Nelumbo nucifera Gaertn. seed) showed potent glucose uptake enhancement activity against L6 myotubes, which results in a hypoglycemic effect. This activity was further investigated, and an active constituent was identified as a single bioactive compound, higenamine 4'-O-beta-d-glucoside. Mechanistic studies employing phosphatidylinositol 3-kinase (PI3K) inhibitor, AMP-activated protein kinase (AMPK) inhibitor, or adrenergic receptor antagonist showed that the compound induced its activity through beta2-adrenergic receptor. Patients with type II diabetes mellitus frequently develop insulin resistance. Owing to the differences between the mechanism of action of insulin and of the isolated compound, the compound or lotus plumule itself may have the possibility of modulating blood glucose levels in insulin-resistant patients effectively.
