FuzilineCAS# 80665-72-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 80665-72-1 | SDF | Download SDF |
| PubChem ID | 14163819 | Appearance | White powder |
| Formula | C24H39NO7 | M.Wt | 453.58 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | 15α-Hydroxyneoline; Senbusine C | ||
| Solubility | Soluble in methan | ||
| Chemical Name | 11-ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,7,8,16-tetrol | ||
| SMILES | CCN1CC2(CCC(C34C2C(C(C31)C5(C6C4CC(C6O)C(C5O)OC)O)OC)O)COC | ||
| Standard InChIKey | FPECZWKKKKZPPP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C24H39NO7/c1-5-25-9-22(10-30-2)7-6-13(26)23-12-8-11-16(27)14(12)24(29,21(28)17(11)31-3)15(20(23)25)18(32-4)19(22)23/h11-21,26-29H,5-10H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Fuziline shows significant insecticidal activity against Nilaparvata legen and Aphis medicagini. Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability. |
| Targets | Antifection |
| In vitro | Alkaloids isolated from the lateral root of Aconitum carmichaelii.[Pubmed: 22907155 ]Molecules, 2012, 17(8):9939-46.Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: Fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). |
| In vivo | The pharmacological research progress of Fuziline and Neoline[Reference: WebLink]《Pharmacy and Clinics of Chinese Materia Medica》 2014-03By analyzing and summarizing pharmacological research literature about Fuziline and Neoline,the pharmacological research of both drugs are found to be mainly concentrated on the cardiovascular system,analgesia,anesthesia,antitumor,insecticidal,and so on.At the same time,Fuziline and Neoline are lack of a comprehensive and systematic pharmacological research. Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study.[Pubmed: 24782408]Biomed Chromatogr. 2014 Dec;28(12):1707-13.
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Fuziline Dilution Calculator
Fuziline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2047 mL | 11.0234 mL | 22.0468 mL | 44.0937 mL | 55.1171 mL |
| 5 mM | 0.4409 mL | 2.2047 mL | 4.4094 mL | 8.8187 mL | 11.0234 mL |
| 10 mM | 0.2205 mL | 1.1023 mL | 2.2047 mL | 4.4094 mL | 5.5117 mL |
| 50 mM | 0.0441 mL | 0.2205 mL | 0.4409 mL | 0.8819 mL | 1.1023 mL |
| 100 mM | 0.022 mL | 0.1102 mL | 0.2205 mL | 0.4409 mL | 0.5512 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study.[Pubmed:24782408]
Biomed Chromatogr. 2014 Dec;28(12):1707-13.
A specific and sensitive UHPLC-qTOF-MS method was developed and validated for quantification of Fuziline in rat plasma after oral administration of three dosages. The analyte was separated on an Acquity UPLC BEH C18 column with a total running time of 3 min using a mobile phase of 0.1% formic acid aqueous solution and methanol (80:20, v/v) at a flow-rate of 0.25 mL/min. The calibration curves for Fuziline showed good linearity in the concentrations ranging from 1 to 200 ng/mL with correlation coefficients >0.997. The precision, accuracy, recovery and stability were deemed acceptable. The method was applied to a pharmacokinetics study of Fuziline in rats. The mean half-life was 5.93, 6.13 and 5.12 h for 1, 2 and 4 mg/kg oral administration of Fuziline, respectively. The peak concentration and area under the concentration-time curve increased linearly with the doses. The sum of these results indicated that, in the range of the doses examined, the pharmacokinetics of Fuziline in rat was based on first-order kinetics.
Alkaloids isolated from the lateral root of Aconitum carmichaelii.[Pubmed:22907155]
Molecules. 2012 Aug 20;17(8):9939-46.
Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: Fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
