Eriosematin

CAS# 168010-17-1

Eriosematin

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Product Name & Size Price Stock
Eriosematin: 5mg $725 In Stock
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Quality Control of Eriosematin

Number of papers citing our products

Chemical structure

Eriosematin

3D structure

Chemical Properties of Eriosematin

Cas No. 168010-17-1 SDF Download SDF
PubChem ID 10358150 Appearance Powder
Formula C19H20O4 M.Wt 312.36
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-hydroxy-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one
SMILES CC(=CCC1=C2C(=C(C3=C1OC=CC3=O)O)C=CC(O2)(C)C)C
Standard InChIKey NYFIMGDPCRCSAF-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H20O4/c1-11(2)5-6-13-17-12(7-9-19(3,4)23-17)16(21)15-14(20)8-10-22-18(13)15/h5,7-10,21H,6H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Eriosematin

The herbs of Flemingia philippinensis

Biological Activity of Eriosematin

In vitro

Electrochemical Behaviour and Antioxidant Activity of Some Natural Polyphenols[Reference: WebLink]

Helvetica Chimica Acta, 2010,79(4):1147-1158.


METHODS AND RESULTS:
A number of natural polyphenols (chlorogenic acid (9), cordigol (11), cordigone (12), danthrone (1), 1,5-dihydroxy-3-methoxyxanthone (2), Eriosematin (7), flemichin D (8), frutinone A (6), mangiferin (4), quercetin (5), 1,3,6,7-tetrahydroxyxanthone (3) and verbascoside (10)) were investigated for their redox properties using cyclic voltammetry. The antioxidant properties of these compounds were also examined in two models, namely lipid peroxidation in rat synaptosomes and AAPH-mediated oxidation of serum albumin. Compounds with a catechol group (9, 4, 5, 3 and 10) were oxidized below 0.4 V and inhibited lipid peroxidation with IC50 values between 2 and 8 μM. Compounds having one or more isolated phenolic groups and showing an oxidation potential between 0.45 and 0.8 V (11, 12 and 8) inhibited lipid peroxidation with IC50 between 7 and 9 μM, except 2 (0.45 V), danthrone (0.96 V) and Eriosematin which showed no or modest antioxidant activity.
CONCLUSIONS:
Some of the investigated compounds also protected albumin from oxidation, but no structure-activity relationship was apparent, suggesting that other factors beside redox potential influence this activity.

Protocol of Eriosematin

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):724-6.

Flavonoids from roots of Flemingia philippinensis.[Pubmed: 19624015]

To investigate the chemical constituents of the roots of Flemingia philippinensis.
METHODS AND RESULTS:
Silica gel, ODS silica gel and Sephadex LH-20 column chromatography were employed for the isolation and purification. The structures were identified on the basis of spectral data (MS, 1H-NMR and 13C-NMR) and chemical evidence. Seven compounds were isolated from the 75% ethanolic extract of the roots of F. philippinensis and identified as follows: flemiphilippinin D (1), dorsmanins I (2), osajin (3), Eriosematin (4), lupinalbin A (5), genistein (6) and 3'-O-methylorobol (7).
CONCLUSIONS:
The compounds 2, 3 and 4 were isolated from the genus Flemingia for the first time. The compounds 2 and 4 were obtained from the Flemingia philippinensis for the first time.

Eriosematin Dilution Calculator

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Eriosematin Molarity Calculator

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Preparing Stock Solutions of Eriosematin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2014 mL 16.0072 mL 32.0143 mL 64.0287 mL 80.0359 mL
5 mM 0.6403 mL 3.2014 mL 6.4029 mL 12.8057 mL 16.0072 mL
10 mM 0.3201 mL 1.6007 mL 3.2014 mL 6.4029 mL 8.0036 mL
50 mM 0.064 mL 0.3201 mL 0.6403 mL 1.2806 mL 1.6007 mL
100 mM 0.032 mL 0.1601 mL 0.3201 mL 0.6403 mL 0.8004 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Eriosematin

[Flavonoids from roots of Flemingia philippinensis].[Pubmed:19624015]

Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):724-6.

OBJECTIVE: To investigate the chemical constituents of the roots of Flemingia philippinensis. METHOD: Silica gel, ODS silica gel and Sephadex LH-20 column chromatography were employed for the isolation and purification. The structures were identified on the basis of spectral data (MS, 1H-NMR and 13C-NMR) and chemical evidence. RESULT: Seven compounds were isolated from the 75% ethanolic extract of the roots of F. philippinensis and identified as follows: flemiphilippinin D (1), dorsmanins I (2), osajin (3), Eriosematin (4), lupinalbin A (5), genistein (6) and 3'-O-methylorobol (7). CONCLUSION: The compounds 2, 3 and 4 were isolated from the genus Flemingia for the first time. The compounds 2 and 4 were obtained from the Flemingia philippinensis for the first time.

Description

Eriosematin is a compound from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property.

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