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Dehydropachymic acid

CAS# 77012-31-8

Dehydropachymic acid

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Product Name & Size Price Stock
Dehydropachymic acid: 5mg $213 In Stock
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Quality Control of Dehydropachymic acid

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Chemical structure

Dehydropachymic acid

3D structure

Chemical Properties of Dehydropachymic acid

Cas No. 77012-31-8 SDF Download SDF
PubChem ID 15226717 Appearance Powder
Formula C33H50O5 M.Wt 526.8
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in chloroform
Chemical Name (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3-acetyloxy-16-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
SMILES CC(C)C(=C)CCC(C1C(CC2(C1(CC=C3C2=CCC4C3(CCC(C4(C)C)OC(=O)C)C)C)C)O)C(=O)O
Standard InChIKey RWIALJIVPUCERT-DRCQUEPLSA-N
Standard InChI InChI=1S/C33H50O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h12,14,19,22,25-28,35H,3,10-11,13,15-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dehydropachymic acid

The root of Wolfiporia cocos (Schw.) Ryv.

Biological Activity of Dehydropachymic acid

Description1. Dehydropachymic acid shows antiinflammatory activity.
TargetsImmunology & Inflammation related

Dehydropachymic acid Dilution Calculator

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Dehydropachymic acid Molarity Calculator

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Preparing Stock Solutions of Dehydropachymic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8983 mL 9.4913 mL 18.9825 mL 37.9651 mL 47.4563 mL
5 mM 0.3797 mL 1.8983 mL 3.7965 mL 7.593 mL 9.4913 mL
10 mM 0.1898 mL 0.9491 mL 1.8983 mL 3.7965 mL 4.7456 mL
50 mM 0.038 mL 0.1898 mL 0.3797 mL 0.7593 mL 0.9491 mL
100 mM 0.019 mL 0.0949 mL 0.1898 mL 0.3797 mL 0.4746 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dehydropachymic acid

Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.[Pubmed:23588713]

Int J Oncol. 2013 Jun;42(6):1869-74.

Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine. Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), Dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells. In conclusion, triterpenes from P. cocos demonstrate anticancer and anti-invasive effects on human pancreatic cancer cells and can be considered as new therapeutic agents in the treatment of pancreatic cancer.

Triterpenes from the fungus Poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathway.[Pubmed:22083926]

Chem Biodivers. 2011 Nov;8(11):2135-43.

Two new triterpenes, 29-hydroxydehydrotumulosic acid (1) and 29-hydroxyDehydropachymic acid (2), together with six known compounds, Dehydropachymic acid (3), dehydrotumulosic acid (4), 29-hydroxypolyporenic acid C (5), polyporenic acid C (6), tumulosic acid (7), and pachymic acid (8), were isolated from the dried sclerotia of Poria cocos. In the in vitro bioassays, these isolated compounds reduced, in a dose-dependent manner, nitric oxide (NO) production from lipopolysaccharide (LPS)-induced RAW 264.7 cells, with compounds 5 and 6, the IC(50) values of which were 16.8+/-2.7 and 18.2+/-3.3 muM, respectively, exhibiting the greatest inhibition activity. Further Western blot analysis conducted on cells pre-treated with compounds 5 and 6, and luciferase assays on activator protein 1-dependent gene expression revealed that the inhibited NO release was attributed to the reduced expression of iNOs (=inducible NO synthase) enzymes, which might be regulated via the blockade of activator protein-1 signaling pathway.

Description

Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells.

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