Cascaroside ACAS# 53823-08-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 53823-08-8 | SDF | Download SDF |
| PubChem ID | 442727 | Appearance | Yellowish powder |
| Formula | C27H32O14 | M.Wt | 580.5 |
| Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
| Solubility | Sparingly soluble in water | ||
| Chemical Name | (10S)-1-hydroxy-3-(hydroxymethyl)-10-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-10H-anthracen-9-one | ||
| SMILES | C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C(C(C(C(O5)CO)O)O)O)C=C(C=C4O)CO | ||
| Standard InChIKey | MNAYRSRTNMVAPR-ZHVWOXMGSA-N | ||
| Standard InChI | InChI=1S/C27H32O14/c28-6-9-4-11-16(26-24(37)22(35)19(32)14(7-29)39-26)10-2-1-3-13(18(10)21(34)17(11)12(31)5-9)40-27-25(38)23(36)20(33)15(8-30)41-27/h1-5,14-16,19-20,22-33,35-38H,6-8H2/t14-,15-,16+,19-,20-,22+,23+,24-,25-,26+,27-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Reference standards. | |||||
Cascaroside A Dilution Calculator
Cascaroside A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7227 mL | 8.6133 mL | 17.2265 mL | 34.4531 mL | 43.0663 mL |
| 5 mM | 0.3445 mL | 1.7227 mL | 3.4453 mL | 6.8906 mL | 8.6133 mL |
| 10 mM | 0.1723 mL | 0.8613 mL | 1.7227 mL | 3.4453 mL | 4.3066 mL |
| 50 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.6891 mL | 0.8613 mL |
| 100 mM | 0.0172 mL | 0.0861 mL | 0.1723 mL | 0.3445 mL | 0.4307 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation of six anthraquinone diglucosides from cascara sagrada bark by high-performance countercurrent chromatography.[Pubmed:32876395]
J Sep Sci. 2020 Nov;43(21):4036-4046.
In this study, high-performance countercurrent chromatography was employed to isolate six anthraquinone diglucosides, namely, cascarosides A-F, from cascara sagrada (Rhamnus purshiana DC [Rhamnaceae]) bark. The n-butanol-soluble extract of cascara sagrada was separated by off-line two-dimensional high-performance countercurrent chromatography. The first-dimensional high-performance countercurrent chromatography resolved the n-butanol-soluble extract (510 mg) of cascara sagrada using the flow-rate gradient method with a chloroform-methanol-isopropanol-water (6:6:1:4, v/v/v/v, normal-phase mode) system to afford four anthraquinone diglucoside fractions (groups I [cascarosides C-D, 71 mg], II [cascarosides E-F, 56 mg], III [Cascaroside A, 53 mg], and IV [cascaroside B, 31 mg]). Groups I and II were separated by the second-dimensional high-performance countercurrent chromatography using an ethyl acetate-n-butanol-water (7:3:10, v/v/v, normal-phase mode) system to yield cascarosides C (34 mg), D (26 mg), E (19 mg), and F (15 mg). Additionally, one-step preparative-scale high-performance countercurrent chromatography method was developed to isolate large amounts of cascarosides A (389 mg) and B (187 mg) from the water-soluble extract (2.1 g) of cascara sagrada using an ethyl acetate-n-butanol-water (2:8:10, v/v/v, normal-phase mode) system. The current study demonstrated that high-performance countercurrent chromatography is a powerful technique for the isolation of marker compounds from herbal materials.
Inhibitory effects of anthraquinones and bianthraquinones on Epstein-Barr virus activation.[Pubmed:11448529]
Cancer Lett. 2001 Sep 10;170(1):15-8.
Short-term in vitro assays for anti-tumor promoters were carried out for several anthraquinones and bianthraquinones, which were isolated from Cassia siamea and derived from Cascaroside A. Anthraquinone monomers showed higher anti-tumor promoting activity than that of bianthraquinones.
