Aloin BCAS# 28371-16-6 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 28371-16-6 | SDF | Download SDF |
| PubChem ID | 5458894 | Appearance | Yellow powder |
| Formula | C21H22O9 | M.Wt | 418.39 |
| Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
| Synonyms | Aloin-B; Isobarbaloin | ||
| Solubility | DMSO : ≥ 100 mg/mL (239.01 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one | ||
| SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(C=C3C2C4C(C(C(C(O4)CO)O)O)O)CO)O | ||
| Standard InChIKey | AFHJQYHRLPMKHU-QVLOPWTGSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dietary supplementation of aloe components (aloin, aloesin and aloe-gel) can ameliorate intestinal inflammatory responses in a 3% dextran sulfate sodium (DSS)-induced ulcerative colitis rat model, in particular, aloesin is the most potent inhibitor. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation. |
| In vitro | Determination of Aloin A and Aloin B in Aloe vera Raw Materials and Finished Products by High-Performance Liquid Chromatography: Single-Laboratory Validation.[Pubmed: 25902982]J AOAC Int. 2014 Sep-Oct;97(5):1323-8.A single-laboratory validation (SLV) was conducted on an HPLC method for the detection and quantification of aloin A and Aloin B in Aloe vera raw materials and finished products. |
| Structure Identification | Advanced Materials Research, Vols. 634-638, pp. 1241-1246, Jan. 2013Isolation and Purification of Aloin a and Aloin B by High-Speed Counter-Current Chromatography[Reference: WebLink]
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Aloin B Dilution Calculator
Aloin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | 47.8023 mL | 59.7529 mL |
| 5 mM | 0.478 mL | 2.3901 mL | 4.7802 mL | 9.5605 mL | 11.9506 mL |
| 10 mM | 0.239 mL | 1.1951 mL | 2.3901 mL | 4.7802 mL | 5.9753 mL |
| 50 mM | 0.0478 mL | 0.239 mL | 0.478 mL | 0.956 mL | 1.1951 mL |
| 100 mM | 0.0239 mL | 0.1195 mL | 0.239 mL | 0.478 mL | 0.5975 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Aloin B is one isomer of Aloin; Aloin is a physiologically active anthraquinone present in aloe.
References:
[1]. Fani M, et al. Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. J Oral Sci. 2012 Mar;54(1):15-21.
[2]. Abd-Alla HI, et al. New bioactive compounds from Aloe hijazensis. Nat Prod Res. 2009;23(11):1035-49.
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Determination of Aloin A and Aloin B in Aloe vera Raw Materials and Finished Products by High-Performance Liquid Chromatography: Single-Laboratory Validation.[Pubmed:25902982]
J AOAC Int. 2014 Sep-Oct;97(5):1323-8.
A single-laboratory validation (SLV) was conducted on an HPLC method for the detection and quantification of aloin A and Aloin B in Aloe vera raw materials and finished products. An extraction procedure using sonication with an acidified solvent was used for solid test materials while liquid test materials only required dilution, if necessary, prior to filtration and analysis. Separation was achieved using a fused core C18 column in 18 min under isocratic elution conditions allowing for a single analyte (aloin A) calibration curve to quantify both aloins. Adequate chromatographic resolution (Rs >/= 1) was achieved for aloin A and Aloin B. The calibration curves for aloin A exhibited coefficients of determination (r(2)) of >/= 99.9% over the linear range of 0.3-50 mug/mL. The LOD values were 0.092 and 0.087 mug/mL, and LOQ 0.23 and 0.21 mug/mL for aloin A and Aloin B, respectively. Repeatability studies were performed on nine test materials on each of 3 separate days, with five of the test materials determined to be above the LOQ having repeatability RSD (RSDr) values ranging from 0.61 to 6.30%. Method accuracy was determined through a spike recovery study on both liquid and solid matrixes at three different levels: low, medium, and high. For both aloins, the recovery in the liquid matrix ranged from 92.7 to 106.3% with an RSDr of 0.15 to 4.30%, while for the solid matrix, the recovery ranged from 84.4 to 108.9% with an RSDr of 0.23 to 3.84%. Based on the results of the SLV study, it is recommended that this method be evaluated for reproducibility through a collaborative study.
