BenzanilideCAS# 93-98-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 93-98-1 | SDF | Download SDF |
| PubChem ID | 7168 | Appearance | Powder |
| Formula | C13H11NO | M.Wt | 197 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | N-phenylbenzamide | ||
| SMILES | C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2 | ||
| Standard InChIKey | ZVSKZLHKADLHSD-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H11NO/c15-13(11-7-3-1-4-8-11)14-12-9-5-2-6-10-12/h1-10H,(H,14,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Benzanilide Dilution Calculator
Benzanilide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.0761 mL | 25.3807 mL | 50.7614 mL | 101.5228 mL | 126.9036 mL |
| 5 mM | 1.0152 mL | 5.0761 mL | 10.1523 mL | 20.3046 mL | 25.3807 mL |
| 10 mM | 0.5076 mL | 2.5381 mL | 5.0761 mL | 10.1523 mL | 12.6904 mL |
| 50 mM | 0.1015 mL | 0.5076 mL | 1.0152 mL | 2.0305 mL | 2.5381 mL |
| 100 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.0152 mL | 1.269 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides.[Pubmed:26730945]
PLoS One. 2016 Jan 5;11(1):e0145615.
The cytotoxicity of 27 Benzanilides and dithioBenzanilides built on a stilbene scaffold and possessing various functional groups in aromatic rings previously described for their spasmolytic properties was assayed on three human cancer cell lines (A549 -lung adenocarcinoma, MCF-7 estrogen dependent breast adenocarcinoma and MDA-MB-231 estrogen independent breast adenocarcinoma) and 2 non-tumorigenic cell lines (CCD39Lu-lung fibroblasts, MCF-12A - breast epithelial). Three compounds (6, 15 and 18) showed selective antiproliferative activity against estrogen dependent MCF-7 cancer cells and their estrogenic activity was further confirmed in MCF-7 transfected with an estrogen receptor reporter plasmid and in HEK239 cells over-expressing the estrogen receptor alpha (ERalpha). Compound 18 is especially interesting as a potential candidate for therapy since it is highly toxic and selective towards estrogen dependent MCF7 cell lines (IC50 = 5.07 muM versus more than 100 muM for MDA-MB-231) and almost innocuous for normal breast cells (IC50 = 91.46 muM for MCF-12A). Docking studies have shown that compound 18 interacts with the receptor in the same cavity as estradiol although the extra aromatic ring is involved in additional binding interactions with residue W383. The role of W383 and the extended binding mode were confirmed by site-directed mutagenesis.
