BambuterolCAS# 81732-65-2 |
- Bax inhibitor peptide, negative control
Catalog No.:BCC2395
CAS No.:1315378-74-5
- Bax channel blocker
Catalog No.:BCC2392
CAS No.:335165-68-9
- PRIMA-1
Catalog No.:BCC2413
CAS No.:5608-24-2
- Bax inhibitor peptide V5
Catalog No.:BCC2394
CAS No.:579492-81-2
- Bax inhibitor peptide P5
Catalog No.:BCC2393
CAS No.:579492-83-4
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 81732-65-2 | SDF | Download SDF |
| PubChem ID | 54766 | Appearance | Powder |
| Formula | C18H29N3O5 | M.Wt | 367.44 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | >17.3mg/mL in DMSO with gentle warming | ||
| Chemical Name | [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate | ||
| SMILES | CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O | ||
| Standard InChIKey | ANZXOIAKUNOVQU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Bambuterol Dilution Calculator
Bambuterol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7215 mL | 13.6077 mL | 27.2153 mL | 54.4307 mL | 68.0383 mL |
| 5 mM | 0.5443 mL | 2.7215 mL | 5.4431 mL | 10.8861 mL | 13.6077 mL |
| 10 mM | 0.2722 mL | 1.3608 mL | 2.7215 mL | 5.4431 mL | 6.8038 mL |
| 50 mM | 0.0544 mL | 0.2722 mL | 0.5443 mL | 1.0886 mL | 1.3608 mL |
| 100 mM | 0.0272 mL | 0.1361 mL | 0.2722 mL | 0.5443 mL | 0.6804 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- PSI-6130
Catalog No.:BCC1870
CAS No.:817204-33-4
- Rhmannioside D
Catalog No.:BCN2362
CAS No.:81720-08-3
- Rehmannioside C
Catalog No.:BCN8183
CAS No.:81720-07-2
- Rehmannioside B
Catalog No.:BCN8468
CAS No.:81720-06-1
- Rehmannioside A
Catalog No.:BCN2885
CAS No.:81720-05-0
- 18-Beta-hydroxy-3-epi-alpha-yohimbine
Catalog No.:BCN3518
CAS No.:81703-06-2
- 3-Dehydro-15-deoxoeucosterol
Catalog No.:BCN4351
CAS No.:81678-46-8
- Canusesnol A
Catalog No.:BCN4350
CAS No.:816456-90-3
- Withaperuvin C
Catalog No.:BCN6727
CAS No.:81644-34-0
- Neuromedin C (porcine)
Catalog No.:BCC5832
CAS No.:81608-30-2
- 2-Pentadecenedioic acid
Catalog No.:BCN3666
CAS No.:81588-35-4
- Forsythoside B
Catalog No.:BCN1205
CAS No.:81525-13-5
- Praeruptorin B
Catalog No.:BCN4988
CAS No.:81740-07-0
- Methimepip dihydrobromide
Catalog No.:BCC7524
CAS No.:817636-54-7
- Quinocetone
Catalog No.:BCC9133
CAS No.:81810-66-4
- Neotriptophenolide
Catalog No.:BCN8059
CAS No.:81827-74-9
- Seneciocannabine
Catalog No.:BCN2128
CAS No.:81855-31-4
- Forskolin J
Catalog No.:BCN4352
CAS No.:81873-08-7
- Ganoderic acid B
Catalog No.:BCN3034
CAS No.:81907-61-1
- Ganoderic acid A
Catalog No.:BCN3033
CAS No.:81907-62-2
- 5,19-Epoxy-25-methoxycucurbita-6,23-dien-3-ol
Catalog No.:BCN1341
CAS No.:81910-39-6
- Momordicoside I aglycone
Catalog No.:BCN4353
CAS No.:81910-41-0
- Polyphyllin H
Catalog No.:BCN2834
CAS No.:81917-50-2
- Zofenopril calcium
Catalog No.:BCC5229
CAS No.:81938-43-4
In vivo metabolism study of (R)-bambuterol in humans using ultra high performance liquid chromatography with tandem mass spectrometry.[Pubmed:27273913]
J Sep Sci. 2016 Aug;39(15):2896-906.
(R)-Bambuterol, a selective beta2-adrenoceptor agonist, has been approved as a new drug for the treatment of asthma and chronic obstructive pulmonary disease by the China Food and Drug Administration and is currently under phase I clinical trials. In this study, a combined method based on ultra high performance liquid chromatography with triple quadrupole mass spectrometry and ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry was employed for the identification of the major metabolites of (R)-Bambuterol in human plasma and urine after an oral dose of 10 mg. The metabolites were separated by gradient elution program and different sample preparation methods were compared. Totally, 12 metabolites of (R)-Bambuterol were identified, including four metabolites in plasma and all 12 metabolites in urine. Among these, four metabolites are reported for the first time. The possible metabolic pathways of (R)-Bambuterol were subsequently proposed. The results indicated that (R)-Bambuterol was metabolized via hydrolysis, demethylation, oxygenation, glucuronidation, and sulfation pathways in vivo. This study revealed that this combined method was accurate and sensitive to identify the possible metabolites and to better understand the metabolism of (R)-Bambuterol in vivo.
Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.[Pubmed:27744187]
Eur J Med Chem. 2017 Jan 27;126:61-71.
An increase activity of butyrylcholinesterase is believed to contribute to Alzheimer's disease. Bambuterol is a known potent inhibitor of butyrylcholinesterase, but it has undesired cardiac effects and less lipophilicity. Thirteen Bambuterol analogues were synthesized using 1-(3, 5-dihydroxyphenyl) ethanone as a starting material. In-vitro cholinesterase assay established that the majority of the compounds are specific butyrylcholinesterase inhibitors. Out of the 13 compounds, two Bambuterol derivatives, BD-6 and BD-11 exhibited similar efficacies in inhibiting butyrylcholinesterase with fewer effects on heart and enhanced possibilities of permeating through the blood-brain barrier as compared to Bambuterol. These Bambuterol analogues may provide better alternatives for treatments of Alzheimer's disease.
Molecularly imprinted phloroglucinol-formaldehyde-melamine resin prepared in a deep eutectic solvent for selective recognition of clorprenaline and bambuterol in urine.[Pubmed:27998487]
Anal Chim Acta. 2017 Jan 25;951:68-77.
A new molecularly imprinted phloroglucinol-formaldehyde-melamine resin (MIPFMR) was synthesized in a deep eutectic solvent (DES) using phenylephrine as a dummy template. The MIPFMR was used as a solid phase extraction (SPE) sorbent for the selective isolation and recognition of clorprenaline (CLP) and Bambuterol (BAM) in urine. Phloroglucinol and melamine were used as double functional monomers that introduced abundant hydrophilic groups (such as hydroxyl groups, imino groups, and ether linkages) into the MIPFMR, making it compatible with aqueous solvents. In addition, the formation of DES by combining the quaternary ammonium salt of choline chloride with ethylene glycol as a hydrogen bond donor was an environmentally safe alternative to toxic organic solvents such as chloroform and dimethylsulfoxide that are typically used in the preparation of most molecularly imprinted polymers (MIPs). Moreover, MIPFMR-based SPE of CLP and BAM in urine resulted in higher recoveries and purer extracts than those obtained by using other SPE materials (e.g., SCX, C18, HLB, and non-imprinted phloroglucinol-formaldehyde-melamine resin (NIPFMR)). The optimized MIPFMR-SPE-HPLC-UV method had good linearity (r(2) >/= 0.9996) ranging from 15.0 to 3000.0 ng mL(-1) for CLP and BAM, and the recoveries at three spiked levels ranged from 91.7% to 100.1% with RSDs
Synthesis of stable isotope labeled D9 -Mabuterol, D9 -Bambuterol, and D9 -Cimbuterol.[Pubmed:27739098]
J Labelled Comp Radiopharm. 2016 Nov;59(13):546-551.
Three stable and simple synthetic routes of labeled D9 -Mabuterol, D9 -Bambuterol, and D9 -Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to (1) H NMR and liquid chromatography-tandem mass spectrometry.
