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Aristolactam BII

CAS# 53948-09-7

Aristolactam BII

Catalog No. BCN5717----Order now to get a substantial discount!

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Aristolactam BII: 5mg $828 In Stock
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Quality Control of Aristolactam BII

Number of papers citing our products

Chemical structure

Aristolactam BII

3D structure

Chemical Properties of Aristolactam BII

Cas No. 53948-09-7 SDF Download SDF
PubChem ID 162739 Appearance Yellow powder
Formula C17H13NO3 M.Wt 279.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC1=C(C2=C3C(=C1)C(=O)NC3=CC4=CC=CC=C42)OC
Standard InChIKey YHQIYHDLBZXUON-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aristolactam BII

The herbs of Aristolochia debilis Sieb. et Zucc

Biological Activity of Aristolactam BII

Description1. Aristolactam BII exerts its significant neuroprotective effects on glutamate-injured primary cultures of rat cortical cells by directly inhibiting the production of nitric oxide. 2. Aristolactam BII exhibits antimicrobial and antiinflammatory activity. 3. Aristolactam BII shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom.
TargetsNO | HIV

Aristolactam BII Dilution Calculator

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Aristolactam BII Molarity Calculator

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Preparing Stock Solutions of Aristolactam BII

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5804 mL 17.9019 mL 35.8038 mL 71.6076 mL 89.5095 mL
5 mM 0.7161 mL 3.5804 mL 7.1608 mL 14.3215 mL 17.9019 mL
10 mM 0.358 mL 1.7902 mL 3.5804 mL 7.1608 mL 8.9509 mL
50 mM 0.0716 mL 0.358 mL 0.7161 mL 1.4322 mL 1.7902 mL
100 mM 0.0358 mL 0.179 mL 0.358 mL 0.7161 mL 0.8951 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aristolactam BII

Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production.[Pubmed:15124081]

Planta Med. 2004 May;70(5):391-6.

Saurolactam and Aristolactam BII, aristolactam-type alkaloids isolated from the aerial part of Saururus chinensis (Lour.) Ball (Saururaceae), showed significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. The action mechanism of Aristolactam BII, the more potent neuroprotective compound, was investigated using primary cultures of rat cortical cells as an in vitro system. Aristolactam BII attenuated glutamate-induced neurotoxicity significantly when it was added immediately or up to 9 h after the excitotoxic glutamate challenge. The alkaloid could not protect cultured neuronal cells from neurotoxicity induced by kainic acid or N-methyl- D-aspartate in a pre-treatment paradigm. However, Aristolactam BII successfully reduced the overproduction of nitric oxide and the level of cellular peroxide in cultured neurons when it was treated as a post-treatment paradigm. These results may suggest that Aristolactam BII exerts its significant neuroprotective effects on glutamate-injured primary cultures of rat cortical cells by directly inhibiting the production of nitric oxide.

Aristolactams, 1-(2-C-methyl-beta-D-ribofuranosyl)-uracil and other bioactive constituents of Toussaintia orientalis.[Pubmed:20334138]

Nat Prod Commun. 2010 Feb;5(2):253-8.

The new aristolactam alkaloid toussalactam {2-hydroxy-1,6-dimethoxy-5H-dibenzo[cdf]indol-4-one} and the known ones, namely aristolactam AII, Aristolactam BII, piperolactam C and aristolactam FII; 1-(2-C-methyl-beta-D-ribofuranosyl)-uracil, 3,4,5-trimethoxyphenyl-beta-D-glucopyranoside, and three catechinoids were isolated from the cytotoxic Toussaintia orientalis Verdc stem and root bark extracts, and their structures established based on analysis of spectroscopic data. The aristolactams exhibited antimicrobial and antiinflammatory activity, aristolactam FII showing almost the same level of activity as the standard anti-inflammatory agent Indomethacin. The compounds also exhibited either mild or no antiproliferative and cytotoxic activities, except aristolactam FII that showed the same level of cytotoxicity as the standard drug Camptothecin. 1-(2-C-Methyl-beta-D-ribofuranosyl)-uracil, which is being reported for the first time as a natural product, was inactive in the antibacterial, antifungal, antiinflammatory, antiproliferative and cytotoxicity assays.

A new conjugated amide-dimer from the aerial parts of Piper submultinerve.[Pubmed:22117113]

Nat Prod Res. 2012;26(19):1824-30.

Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and Aristolactam BII (8) showed significant activities in the anti-syncytium assay using (DeltaTat/Rev)MC99 virus and 1A2 cell line system, whereas 2 was most active (EC(5)(0) 35.1 microM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC(5)(0) 50.8 microM.

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