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8alpha-(2-Methylacryloyloxy)hirsutinolide

CAS# 188293-70-1

8alpha-(2-Methylacryloyloxy)hirsutinolide

Catalog No. BCN7109----Order now to get a substantial discount!

Product Name & Size Price Stock
8alpha-(2-Methylacryloyloxy)hirsutinolide:5mg Please Inquire In Stock
8alpha-(2-Methylacryloyloxy)hirsutinolide:10mg Please Inquire In Stock
8alpha-(2-Methylacryloyloxy)hirsutinolide:20mg Please Inquire In Stock
8alpha-(2-Methylacryloyloxy)hirsutinolide:50mg Please Inquire In Stock

Quality Control of 8alpha-(2-Methylacryloyloxy)hirsutinolide

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Chemical structure

8alpha-(2-Methylacryloyloxy)hirsutinolide

3D structure

Chemical Properties of 8alpha-(2-Methylacryloyloxy)hirsutinolide

Cas No. 188293-70-1 SDF Download SDF
PubChem ID 102064544 Appearance Powder
Formula C19H24O7 M.Wt 364.39
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CC(C2=C(C(=O)OC2=CC3(CCC1(O3)O)C)CO)OC(=O)C(=C)C
Standard InChIKey VSNXXZXCVFUXKD-LYUOXOCJSA-N
Standard InChI InChI=1S/C19H24O7/c1-10(2)16(21)24-13-7-11(3)19(23)6-5-18(4,26-19)8-14-15(13)12(9-20)17(22)25-14/h8,11,13,20,23H,1,5-7,9H2,2-4H3/b14-8+/t11-,13+,18-,19+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 8alpha-(2-Methylacryloyloxy)hirsutinolide

The herbs of Vernonia cinerea.

Protocol of 8alpha-(2-Methylacryloyloxy)hirsutinolide

Kinase Assay

Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence.[Pubmed: 25857233]

Drug Metabolism and Pharmacokinetics, 2015, 30(2):174-181.

The human cytochrome P450 2A6 (CYP2A6) and monoamine oxidases (MAO-A and MAO-B), catalyzing nicotine and dopamine metabolisms, respectively, are two therapeutic targets of nicotine dependence. Vernonia cinerea, a medicinal plant commonly used for treatment of diseases such as asthma and bronchitis, has been shown reducing tobacco dependence effect among tobacco users.
METHODS AND RESULTS:
In the present study, we found eight active compounds isolated from V. cinerea that comprise inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes using activity-guided assays, with coumarin as substrate of CYP2A6 and kynuramine of MAOs. These compounds were three flavones (apigenin, chrysoeriol, luteolin), one flavonol (quercetin), and four hirsutinolide-type sesquiterpene lactones (8alpha-(2-Methylacryloyloxy)hirsutinolide-13-O-acetate, 8α-(4-hydroxymethacryloyloxy)-hirsutinolide-13-O-acetate, 8α-tigloyloxyhirsutinolide-13-O-acetate, and 8α-(4-hydroxytigloyloxy)-hirsutinolide-13-O-acetate). Modes and kinetics of inhibition against the three enzymes were determined. Flavonoids possessed strong inhibitory effect on CYP2A6 in reversible mode, while inhibition by hirsutinolides was mechanism-based (NADPH-, concentration-, and time-dependence) and irreversible. Inhibition by hirsutinolides could not be reversed by dialysis and by addition of trapping agents or potassium ferricyanide. Flavonoids inhibited MAOs with variable degrees and were more prominent in inhibition toward MAO-A than hirsutinolides, while two of hirsutinolides inhibited MAO-B approximately comparable to two flavonoids.
CONCLUSIONS:
These results could have implications in combination of drug therapy for smoking cessation.

8alpha-(2-Methylacryloyloxy)hirsutinolide Dilution Calculator

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8alpha-(2-Methylacryloyloxy)hirsutinolide Molarity Calculator

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Preparing Stock Solutions of 8alpha-(2-Methylacryloyloxy)hirsutinolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7443 mL 13.7216 mL 27.4431 mL 54.8862 mL 68.6078 mL
5 mM 0.5489 mL 2.7443 mL 5.4886 mL 10.9772 mL 13.7216 mL
10 mM 0.2744 mL 1.3722 mL 2.7443 mL 5.4886 mL 6.8608 mL
50 mM 0.0549 mL 0.2744 mL 0.5489 mL 1.0977 mL 1.3722 mL
100 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.5489 mL 0.6861 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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