Home >> Research Area >>Natural Products>>Flavonoids>> 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

CAS# 1605304-56-0

5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

Catalog No. BCN6847----Order now to get a substantial discount!

Product Name & Size Price Stock
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone:5mg Please Inquire In Stock
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone:10mg Please Inquire In Stock
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone:20mg Please Inquire In Stock
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone:50mg Please Inquire In Stock

Quality Control of 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

Number of papers citing our products

Chemical structure

5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

3D structure

Chemical Properties of 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

Cas No. 1605304-56-0 SDF Download SDF
PubChem ID 91825843 Appearance Powder
Formula C26H28O7 M.Wt 452.50
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,4-dihydroxyphenyl)-8-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-3-methoxychromen-4-one
SMILES CC(=CCCC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)OC)C3=CC(=C(C=C3)O)O)O)O)C)C
Standard InChIKey AHZUPZUDBQBABD-OVCLIPMQSA-N
Standard InChI InChI=1S/C26H28O7/c1-14(2)6-5-7-15(3)8-10-17-19(28)13-21(30)22-23(31)26(32-4)24(33-25(17)22)16-9-11-18(27)20(29)12-16/h6,8-9,11-13,27-30H,5,7,10H2,1-4H3/b15-8+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

The barks of Broussonetia papyrifera.

Biological Activity of 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

Description5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone is a natural product from Broussonetia papyrifera.
In vitro

Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo.[Reference: WebLink]

Phytochemistry Letters, 2013, 6(3):331-336.


METHODS AND RESULTS:
Two new prenylflavones 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone (1) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (2), as well as four known ones, uralenol (3), papyriflavonol A (4), broussoflavonol B (5) and broussochalcone A (6) were isolated and purified from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera. Their structures were determined with the spectroscopic methods including HR-EI-MS, 1D and 2D NMR. We found that compounds 2–6 showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. The IC50 values of compounds 2 and 5 were 4.41 and 4.19 μM respectively after the treatment of 72 h. We also found that compounds 2 and 5 strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.
CONCLUSIONS:
Our results demonstrated that prenylflavones from B. Papyrifera exhibit potent anti-tumor activity.

5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2099 mL 11.0497 mL 22.0994 mL 44.1989 mL 55.2486 mL
5 mM 0.442 mL 2.2099 mL 4.4199 mL 8.8398 mL 11.0497 mL
10 mM 0.221 mL 1.105 mL 2.2099 mL 4.4199 mL 5.5249 mL
50 mM 0.0442 mL 0.221 mL 0.442 mL 0.884 mL 1.105 mL
100 mM 0.0221 mL 0.1105 mL 0.221 mL 0.442 mL 0.5525 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo.

Phytochemistry Letters, 2013, 6(3):331-336.

Two new prenylflavones 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone (1) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (2), as well as four known ones, uralenol (3), papyriflavonol A (4), broussoflavonol B (5) and broussochalcone A (6) were isolated and purified from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera. Their structures were determined with the spectroscopic methods including HR-EI-MS, 1D and 2D NMR. We found that compounds 2–6 showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. The IC50 values of compounds 2 and 5 were 4.41 and 4.19 μM respectively after the treatment of 72 h. We also found that compounds 2 and 5 strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo. Our results demonstrated that prenylflavones from B. Papyrifera exhibit potent anti-tumor activity.

Keywords:

5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone,1605304-56-0,Natural Products, buy 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone , 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone supplier , purchase 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone , 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone cost , 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone manufacturer , order 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone , high purity 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: