Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8636 | (Z)-Aldosecologanin |
| (Z)-Aldosecologanin is a natural product from Lonicera japonica. | |
| BCN8638 | Bruceoside A |
| Bruceoside A could be transformed into the potent anticancer component brusatol in vivo, rather than its direct deglycosylated metabolite bruceosin. It significantly inhibited P-388 lymphocytic leukemic cell RNA and protein synthesis in tissue culture. | |
| BCC9214 | Aflatoxin G1 |
| Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma. AFG1 induces TNF-α-dependent lung inflammation, which upregulates CYP2A13 to promote the metabolic activation of AFG1 and enhance oxidative DNA damage in AT-II cells. Dillapiol as a specific inhibitor of aflatoxin G1 production, it inhibited aflatoxin G1 production by Aspergillus parasiticus with an IC50 value of 0.15 microM. | |
| BCN8371 | Notoginsenoside S |
| Notoginsenoside S may have hepatoprotective effects. | |
| BCN8445 | Cycleanine |
| The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. Cycleanine, like its isomer – tetrandrine isolated from T. subcordata, could be a potential new anti-ovarian cancer agent acting through the apoptosis pathway. It also shows antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 µM.Cycleanine may have anti-inflammatory activity. Cycleanine markedly inhibited Na(+),K(+)-ATPase activity with an IC(50) value of 6.2 x 10(-4)M. It slightly inhibited Mg(2+)-ATPase, H(+)-ATPase, and Ca(2+)-ATPase, it might interact with the enzyme in Na.E(1)-P form and prevents the reaction step from Na.E(1)-P to E(2)-P. | |
| BCN3492 | 16R-sitsirikine |
| Sitsirikine is a natural product from Catharanthus roseus. | |
| BCN8314 | Protostemotinine |
| Protostemotinine is a natural product from Stemona japonica. | |
| BCN8687 | Licochalcone D |
| Licochalcone D has anti-inflammatory, and anti-allergic activities, it shows suppression ability of nitric oxide (NO) production, it also suppresses degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. It may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. | |
