Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2476 | Dihydromethysticin |
| 1. The induction of CYP3A23 by dihydromethysticin and desmethoxyyangonin involves transcription activation, probably through a pregnane X receptor (PXR).-independent or PXR-involved indirect mechanism. 2. Dihydromethysticin non-competitively inhibits the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels. | |
| BCN2499 | Isocryptotanshinone |
| 1. Isocryptotanshinone inhibits MCF-7 cell proliferation by inducing apoptosis and activating MAPK signaling pathways. 2. Isocryptotanshinone is a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. 3. Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM. (1) PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. | |
| BCN2501 | Isotanshinone IIA |
| 1. Isotanshinone IIA non-competitively inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 11.4±0.6 μM. (1) PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. | |
| BCN2502 | Isovanillin |
| Isovanillin is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical. Isovanillin is a selective inhibitor of aldehyde oxidase, is metabolized by aldehyde dehydrogenase into isovanillic acid ,and the LD50 (rat, ipr) is 1276 mg/kg. | |
| BCN2515 | Broussonetine A |
| 1. Broussonetines A-H are glycosidase inhibitors. | |
