Neuroscience Research

Neuroscience is the study of the nervous system - one of the major mammalian systems responsible for sustaining life. The central nervous system (CNS) and peripheral nervous system (PNS) work in concert to coordinate basic functions such as moving and breathing, as well as 'higher order' functions including thought, speech and emotion.

Neuroscience Research Products Areas

Products for Neuroscience Research - Page 121

Cat.No. Product Name Information/Activity
BCC6358 ICA 121431 ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM).
BCC6327 Jingzhaotoxin III 925463-91-8
BCC7618 KC 12291 hydrochloride 181936-98-1
BCC7794 Licarbazepine 29331-92-8
BCC4677 Mexiletine HCl Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker.
BCC5077 Oxcarbazepine Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.
BCC6328 Phrixotoxin 3 880886-00-0
BCC6103 ProTx II ProTx II is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. ProTx-II inhibits sodium channels by decreasing channel conductance and shifting activation to more positive potentials and blocks action potential propagation in nociceptors.
BCC6906 QX 222 5369-00-6
BCC6889 QX 314 bromide QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.