Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Research Products Areas

Products for Cancer Research - Page 68

Cat.No. Product Name Information/Activity
BCN2194 beta-Estradiol Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
BCC7701 FERb 033 1111084-78-6
BCC7557 GSK 4716 GSK-4716 is a selective ERRβ/γ agonist.
BCN2750 27-Hydroxycholesterol 27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.
BCN5946 Liquiritigenin Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
BCC7062 PPT Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).
BCC7669 WAY 200070 WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
BCC1081 Fulvestrant Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and apoptosis and has antitumor efficacy.
BCC7225 MPP dihydrochloride MPP dihydrochloride is a highly selective estrogen receptor alpha (ERα) antagonist. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
BCC7447 PHTPP PHTPP is a selective ERβ antagonist.