Taraxasterol acetateCAS# 6426-43-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 6426-43-3 | SDF | Download SDF |
| PubChem ID | 344468 | Appearance | White powder |
| Formula | C32H52O2 | M.Wt | 468.8 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | Isolactucerol acetate; Pyrethrol acetate; Saussurol acetate | ||
| Solubility | Freely soluble in chloroform; soluble in ethanol and methanol; insoluble in water | ||
| Chemical Name | (4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,6a,7,8,9,10,12,12a,13,14,14a-hexadecahydropicen-3-yl) acetate | ||
| SMILES | CC1C2C3CCC4C5(CCC(C(C5CCC4(C3(CCC2(CCC1=C)C)C)C)(C)C)OC(=O)C)C | ||
| Standard InChIKey | SFEUTIOWNUGQMZ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C32H52O2/c1-20-12-15-29(6)18-19-31(8)23(27(29)21(20)2)10-11-25-30(7)16-14-26(34-22(3)33)28(4,5)24(30)13-17-32(25,31)9/h21,23-27H,1,10-19H2,2-9H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Taraxasterol acetate has anti-inflammatory activity in bino rats against carrageenan, formaldehyde and adjuvant induced inflammations in doses between 10 and 100 mg/kg. Taraxasterol acetate also displays potential antibacterial activities. |
| Targets | TNF-α | IFN-γ | IL Receptor | NF-kB |
| In vitro | Effect of Pluchea lanceolata bioactives in LPS-induced neuroinflammation in C6 rat glial cells.[Pubmed: 24101125]Naunyn Schmiedebergs Arch Pharmacol. 2014 Feb;387(2):119-27.Neuroinflammation plays a significant role in various chronic and acute pathological conditions of the central nervous system. In the Indian system of medicine, Pluchea lanceolata is used to treat the neurological disorders. Antibacterial triterpenes from Centipeda minima (Compositae).[Reference: WebLink]Acta Botanica Yunnanica, 2007, 29(4):479-482.
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Taraxasterol acetate Dilution Calculator
Taraxasterol acetate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1331 mL | 10.6655 mL | 21.3311 mL | 42.6621 mL | 53.3276 mL |
| 5 mM | 0.4266 mL | 2.1331 mL | 4.2662 mL | 8.5324 mL | 10.6655 mL |
| 10 mM | 0.2133 mL | 1.0666 mL | 2.1331 mL | 4.2662 mL | 5.3328 mL |
| 50 mM | 0.0427 mL | 0.2133 mL | 0.4266 mL | 0.8532 mL | 1.0666 mL |
| 100 mM | 0.0213 mL | 0.1067 mL | 0.2133 mL | 0.4266 mL | 0.5333 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effect of Pluchea lanceolata bioactives in LPS-induced neuroinflammation in C6 rat glial cells.[Pubmed:24101125]
Naunyn Schmiedebergs Arch Pharmacol. 2014 Feb;387(2):119-27.
Neuroinflammation plays a significant role in various chronic and acute pathological conditions of the central nervous system. In the Indian system of medicine, Pluchea lanceolata is used to treat the neurological disorders. We investigated the effect of major pentacyclic triterpene and its naturally occurring acetate derivative isolated from P. lanceolata on lipopolysaccharide (LPS)-stimulated neuroinflammatory condition associated to inflammatory cytokine production in rat astrocytoma cell line (C6). The log concentration dependence of Pluchea bioactive taraxasterol (Tx) significantly (p < 0.05) attenuates the release of pro-inflammatory cytokines, such as TNF-alpha, IFN-gamma, and IL-6, while its in situ produced acetyl derivative, i.e., Taraxasterol acetate (TxAc), did not inhibit the LPS-induced IL-6 production at lower concentration (p > 0.05). Surflex-Dock molecular modeling study was performed to simulate the binding capacity of compounds into the active site of the TNF-alpha (2AZ5), tumor protein P53 (2VUK), and NF-kappa-B (1RAM). The differential inhibition of cytokines by Tx and TxAc was further confirmed by high docking scores showing the high affinity to target proteins. Findings of the study demonstrated the comparatively greater role of Pluchea triterpene than its in situ produced acetate derivate in neuroinflammation-associated disorders.
