Precocene IICAS# 644-06-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 644-06-4 | SDF | Download SDF |
| PubChem ID | 12565 | Appearance | Powder |
| Formula | C13H16O3 | M.Wt | 220.27 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6,7-dimethoxy-2,2-dimethylchromene | ||
| SMILES | CC1(C=CC2=CC(=C(C=C2O1)OC)OC)C | ||
| Standard InChIKey | PTIDGSWTMLSGAH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H16O3/c1-13(2)6-5-9-7-11(14-3)12(15-4)8-10(9)16-13/h5-8H,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Precocene II is a botanically derived chemical that inhibits the production of juvenile hormone (JH) in insects. 2. Precocene II is highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis. 3. Precocene II , an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats. |
| Targets | Antifection |
Precocene II Dilution Calculator
Precocene II Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.5399 mL | 22.6994 mL | 45.3988 mL | 90.7977 mL | 113.4971 mL |
| 5 mM | 0.908 mL | 4.5399 mL | 9.0798 mL | 18.1595 mL | 22.6994 mL |
| 10 mM | 0.454 mL | 2.2699 mL | 4.5399 mL | 9.0798 mL | 11.3497 mL |
| 50 mM | 0.0908 mL | 0.454 mL | 0.908 mL | 1.816 mL | 2.2699 mL |
| 100 mM | 0.0454 mL | 0.227 mL | 0.454 mL | 0.908 mL | 1.135 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effect of precocene II on fatty acid metabolism in the pea aphid, Acyrthosiphon pisum, under cold stress.[Pubmed:15890184]
J Insect Physiol. 2005 Apr;51(4):411-6.
Pea aphids, Acyrthosiphon pisum (Harris), reared at 10 degrees C contain higher levels of fatty acids than those reared at 25 degrees C. This is primarily the result of an accumulation of triacylglycerols containing myristic acid. When aphids reared at 25 degrees C were transferred to 10 degrees C there was a gradual increase in triacylglycerol content that reached a maximum at 16 days post-transfer. Treatment of aphids with Precocene II prior to transfer to 10 degrees C blocked the accumulation of fatty acids including myristic acid. A single application of 2 microg Precocene II/aphid or two applications of 0.5 microg Precocene II/ aphid administered on consecutive days resulted in aphids moved to 10 degrees C maintaining the same fatty acid profile as aphids maintained at 25 degrees C. Aphids that were treated with Precocene II and maintained at 25 degrees C did not show changes in fatty acid profiles. Rearing aphids at 10 degrees C resulted in lower rates of reproduction and lower total numbers of progeny with longer longevity. Treatment with Precocene II significantly decreased the total number of progeny produced at both temperatures. Precocene II did not reduce life span of aphids reared at 25 degrees C, however, the life span of treated aphids reared at 10 degrees C was decreased. The mechanism by which Precocene II prevents the accumulation of myristic acid in aphids reared at 10 degrees C remains to be determined.
Sensitivity of last larval stadium of Chrysomya megacephala (Fabricius) to anti-allatin ageratochromene Precocene II.[Pubmed:21870428]
Indian J Exp Biol. 2011 Aug;49(8):600-8.
Treatment of early and late third instar larvae of economically important insect C. megacephala with the ageratochromene Precocene II resulted into precocious metamorphosis. The other effects included mortality, production of pupal-adult mosaics, reduction in percentage of adult emergence and formation of non-viable deformed adults that died after a few hours of emergence. The application of Precocene II adversely hampered the normal growth, development and metamorphosis of the insect and the results show that Precocene II has vast potential for excellent control of this insect of medico-veterinary importance and can be used in insect pest management programs.
The effects of precocene II on reproduction and development of triatomine bugs (Reduviidae: Triatominae).[Pubmed:7041667]
Am J Trop Med Hyg. 1982 Mar;31(2):416-20.
Precocene II is a botanically derived chemical that inhibits the production of juvenile hormone (JH) in insects. The effects of this anti-JH compound on molting and growth by Rhodnius prolixus and Triatoma dimidiata and reproduction in R. prolixus were tested and the efficacy of Precocene II as a fumigant was assessed. Precocene II induced precocious metamorphosis in both species when applied by either contact exposure or fumigation, and this effect could be prevented by juvenile hormone replacement therapy. The dosage effective in inducing precocious metamorphosis in T. dimidiata was similar to the EC50 previously reported for R. prolixus. The morphology of precocious adultoid T. dimidiata of different instars was similar to Rhodnius adultoids of corresponding instars. However, T. dimidiata was more sensitive than Rhodnius to the molt-inhibiting effects of Precocene II. Rhodnius nymphs were fully susceptible to the anti-JH action of precocene when exposed for 24 hours one week before feeding. Precocene II was highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis.
Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.[Pubmed:2598296]
Chem Biol Interact. 1989;71(2-3):187-99.
Precocene II (6,7-dimethoxy-2,2-dimethyl-2H-benzo[b]pyran), an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats. This investigation was conducted to evaluate the effects of modulation of hepatic glutathione levels on the toxicity of Precocene II. Administration of a toxic dose of Precocene II (175 mg/kg) to male Sprague-Dawley rats rapidly depleted hepatic GSH, produced histopathological changes in the liver, and induced increases in serum aminotransferase activity. Concurrent administration of the cysteine pro-drug L-2-oxothiazolidine-4-carboxylic acid (OTC) prevented these toxic effects of Precocene II. In contrast, pretreatment of rats with DL-buthionine-SR-sulfoximine (BSO), an inhibitor of glutathione synthesis, potentiated the toxicity of an otherwise non-toxic dose of Precocene II (100 mg/kg). These results indicate that glutathione is important for protection from Precocene II-induced hepatotoxicity.
