SyneilesineCAS# 55652-65-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 55652-65-8 | SDF | Download SDF |
| PubChem ID | 6440164 | Appearance | Powder |
| Formula | C19H29NO7 | M.Wt | 383.44 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,5S,6R,7R,11Z)-4-ethyl-5,7-dihydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione | ||
| SMILES | CCC1C(C(C(C(=O)OCC2=CCN(CCC(C2=O)OC1=O)C)(C)O)C)O | ||
| Standard InChIKey | GUCAZZVOPNEPFJ-VZXZMQOTSA-N | ||
| Standard InChI | InChI=1S/C19H29NO7/c1-5-13-15(21)11(2)19(3,25)18(24)26-10-12-6-8-20(4)9-7-14(16(12)22)27-17(13)23/h6,11,13-15,21,25H,5,7-10H2,1-4H3/b12-6-/t11-,13?,14-,15+,19-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Targets | DNA/RNA Synthesis |
Syneilesine Dilution Calculator
Syneilesine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.608 mL | 13.0398 mL | 26.0797 mL | 52.1594 mL | 65.1992 mL |
| 5 mM | 0.5216 mL | 2.608 mL | 5.2159 mL | 10.4319 mL | 13.0398 mL |
| 10 mM | 0.2608 mL | 1.304 mL | 2.608 mL | 5.2159 mL | 6.5199 mL |
| 50 mM | 0.0522 mL | 0.2608 mL | 0.5216 mL | 1.0432 mL | 1.304 mL |
| 100 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.5216 mL | 0.652 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Cepharadione B
Catalog No.:BCN6524
CAS No.:55610-02-1
- Cepharadione A
Catalog No.:BCN3950
CAS No.:55610-01-0
- Aristololactam II
Catalog No.:BCN8095
CAS No.:55610-00-9
- 1-Oxo-4-hydroxy-2-en-4-ethylcyclohexa-5,8-olide
Catalog No.:BCN1417
CAS No.:55604-88-1
- Alverine Citrate
Catalog No.:BCC4619
CAS No.:5560-59-8
- Alliin
Catalog No.:BCN3869
CAS No.:556-27-4
- H-D-Tyr-OH
Catalog No.:BCC3134
CAS No.:556-02-5
- Acesulfame Potassium
Catalog No.:BCC4755
CAS No.:55589-62-3
- Agrimol B
Catalog No.:BCN5017
CAS No.:55576-66-4
- Boc-Phe(4-NH2)-OH
Catalog No.:BCC3153
CAS No.:55533-24-9
- H-1-Nal-OH
Catalog No.:BCC3282
CAS No.:55516-54-6
- Biondinin C
Catalog No.:BCN5744
CAS No.:55511-08-5
- Deltonin
Catalog No.:BCC8933
CAS No.:55659-75-1
- Boc-D-Thr-OH
Catalog No.:BCC3453
CAS No.:55674-67-4
- TCN 213
Catalog No.:BCC6123
CAS No.:556803-08-8
- 1-Octacosanol
Catalog No.:BCN2973
CAS No.:557-61-9
- (24S)-24,25-Dihydroxyvitamin D3
Catalog No.:BCC1290
CAS No.:55700-58-8
- Secalciferol
Catalog No.:BCC1942
CAS No.:55721-11-4
- Salinomycin sodium salt
Catalog No.:BCC1917
CAS No.:55721-31-8
- Boc-D-Ile-OH
Catalog No.:BCC3407
CAS No.:55721-65-8
- Stigmasta-4,22-dien-3-one
Catalog No.:BCN5745
CAS No.:55722-32-2
- 3-Deoxo-1Beta-methoxyjioglutolide
Catalog No.:BCN7034
CAS No.:55732-36-0
- Oxoglaucine
Catalog No.:BCN2650
CAS No.:5574-24-3
- Litorin
Catalog No.:BCC5846
CAS No.:55749-97-8
Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes.[Pubmed:4005849]
Cancer Res. 1985 Jul;45(7):3125-9.
Seventeen pyrrolizidine alkaloids were studied with the hepatocyte primary culture-DNA repair test using rat hepatocytes. DNA repair synthesis was elicited by 15 alkaloids, including 11 of unknown carcinogenicity, i.e., senecionine, seneciphylline, jacobine, epoxyseneciphylline, senecicannabine, acetylfukinotoxin, Syneilesine, dihydroclivorine, ligularidine, neoligularidine, and ligularizine. The positive results with these alkaloids of unknown carcinogenicity suggest that they are possibly genotoxic carcinogens. The two pyrrolizidine alkaloids that did not elicit DNA repair were retronecine which lacks a necic acid component and ligularinine which lacks the unsaturated double bond at the 1,2-position of the pyrrolizidine ring. Five pyrrolizidine alkaloids, retronecine, monocrotaline, seneciphylline, senkirkine, and clivorine, were also tested in the DNA repair test with hamster or mouse hepatocytes. These alkaloids, except retronecine, showed a positive response in the test with hamster hepatocytes, but in the test with mouse hepatocytes clivorine in addition to retronecine was also negative. The results indicate a species difference in liver bioactivation of pyrrolizidine alkaloids, implying that there could be species differences in their carcinogenic activities.
