Cepharadione BCAS# 55610-02-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 55610-02-1 | SDF | Download SDF |
| PubChem ID | 189151 | Appearance | Powder |
| Formula | C19H15NO4 | M.Wt | 321.33 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1C2=CC3=CC=CC=C3C4=C2C(=CC(=C4OC)OC)C(=O)C1=O | ||
| Standard InChIKey | AFKGBLKLNRDQFN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H15NO4/c1-20-13-8-10-6-4-5-7-11(10)16-15(13)12(17(21)19(20)22)9-14(23-2)18(16)24-3/h4-9H,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Stephania cepharantha Hayata
| Description | 1. Cepharadione B exhibits strong tyrosinase inhibitory activity with an IC50 value of 170 microM. 2. Cepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. |
| Targets | Tyrosinase |
Cepharadione B Dilution Calculator
Cepharadione B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1121 mL | 15.5603 mL | 31.1207 mL | 62.2413 mL | 77.8016 mL |
| 5 mM | 0.6224 mL | 3.1121 mL | 6.2241 mL | 12.4483 mL | 15.5603 mL |
| 10 mM | 0.3112 mL | 1.556 mL | 3.1121 mL | 6.2241 mL | 7.7802 mL |
| 50 mM | 0.0622 mL | 0.3112 mL | 0.6224 mL | 1.2448 mL | 1.556 mL |
| 100 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.6224 mL | 0.778 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxic alkaloids from Houttuynia cordata.[Pubmed:11794526]
Arch Pharm Res. 2001 Dec;24(6):518-21.
Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norCepharadione B(4), Cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
The constituents and their bioactivities of Houttuynia cordata.[Pubmed:19881272]
Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1227-30.
Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norCepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
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