Rhuscholide ACAS# 944804-58-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 944804-58-4 | SDF | Download SDF |
| PubChem ID | 16655065 | Appearance | Powder |
| Formula | C31H42O3 | M.Wt | 462.7 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-hydroxy-3-propan-2-ylidene-7-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]-1-benzofuran-2-one | ||
| SMILES | CC(=CCCC(=CCCC(=CCCC(=CCC1=C2C(=CC(=C1)O)C(=C(C)C)C(=O)O2)C)C)C)C | ||
| Standard InChIKey | LPJLAXYRFCLYIG-HBKYZHKXSA-N | ||
| Standard InChI | InChI=1S/C31H42O3/c1-21(2)11-8-12-23(5)13-9-14-24(6)15-10-16-25(7)17-18-26-19-27(32)20-28-29(22(3)4)31(33)34-30(26)28/h11,13,15,17,19-20,32H,8-10,12,14,16,18H2,1-7H3/b23-13+,24-15+,25-17+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The stems of Rhus chinensis
| Description | 1. Rhuscholide A possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40. |
| Targets | HIV |
Rhuscholide A Dilution Calculator
Rhuscholide A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1612 mL | 10.8061 mL | 21.6123 mL | 43.2246 mL | 54.0307 mL |
| 5 mM | 0.4322 mL | 2.1612 mL | 4.3225 mL | 8.6449 mL | 10.8061 mL |
| 10 mM | 0.2161 mL | 1.0806 mL | 2.1612 mL | 4.3225 mL | 5.4031 mL |
| 50 mM | 0.0432 mL | 0.2161 mL | 0.4322 mL | 0.8645 mL | 1.0806 mL |
| 100 mM | 0.0216 mL | 0.1081 mL | 0.2161 mL | 0.4322 mL | 0.5403 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis.[Pubmed:17290322]
Planta Med. 2007 Mar;73(3):279-82.
A new benzofuran lactone, Rhuscholide A (1), was isolated from the stems of RHUS CHINENSIS, together with six known compounds: 5-hydroxy-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraenyl)-2(3 H)-benzofuranone (2), betulin (3), betulonic acid (4), moronic acid (5), 3-oxo-6 beta-hydroxyolean-12-en-28-oic acid (6) and 3-oxo-6 beta-hydroxyolean-18-en-28-oic acid (7). Based on 1D, 2D NMR (COSY, HMQC, HMBC) and mass (EI-MS, HR-EI-MS) spectral data, the structure of Rhuscholide A was deduced to be 5-hydroxy-3-(propan-2-ylidene)-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraen yl)-2(3 H)-benzofuranone (1). Anti-HIV-1 bioassays IN VITRO revealed that compound 1 possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40. Compounds 2, 4, 5 and 7 showed moderate anti-HIV-1 activities with EC50 values of 3.70, 5.81, 7.49 and 13.11 microM, respectively.
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