Raucaffricine

CAS# 31282-07-2

Raucaffricine

Catalog No. BCN4653----Order now to get a substantial discount!

Product Name & Size Price Stock
Raucaffricine:5mg Please Inquire In Stock
Raucaffricine:10mg Please Inquire In Stock
Raucaffricine:20mg Please Inquire In Stock
Raucaffricine:50mg Please Inquire In Stock

Quality Control of Raucaffricine

Number of papers citing our products

Chemical structure

Raucaffricine

3D structure

Chemical Properties of Raucaffricine

Cas No. 31282-07-2 SDF Download SDF
PubChem ID 20056255 Appearance Powder
Formula C27H32N2O8 M.Wt 512.56
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC=C1C2CC3C4=NC5=CC=CC=C5C46CC(C2C6OC(=O)C)N3C1OC7C(C(C(C(O7)CO)O)O)O
Standard InChIKey OSJPGOJPRNTSHP-BGYCQZOHSA-N
Standard InChI InChI=1S/C27H32N2O8/c1-3-12-13-8-16-23-27(14-6-4-5-7-15(14)28-23)9-17(19(13)24(27)35-11(2)31)29(16)25(12)37-26-22(34)21(33)20(32)18(10-30)36-26/h3-7,13,16-22,24-26,30,32-34H,8-10H2,1-2H3/b12-3+/t13-,16-,17-,18+,19?,20+,21-,22+,24?,25+,26-,27+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Raucaffricine

The root of Rauvolfia serpentina

Protocol of Raucaffricine

Structure Identification
J Enzyme Inhib Med Chem. 2015 Jun;30(3):472-8.

Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours.[Pubmed: 25140865]


METHODS AND RESULTS:
Insight into the structure and inhibition mechanism of O-β-d-glucosidases by deoxa-pyranosylamine type inhibitors is provided by X-ray analysis of complexes between Raucaffricine and strictosidine glucosidases and N-(cyclohexylmethyl)-, N-(cyclohexyl)- and N-(bromobenzyl)-β-d-gluco-1,5-deoxa-pyranosylamine. All inhibitors anchored exclusively in the catalytic active site by competition with appropriate enzyme substrates.
CONCLUSIONS:
Thus facilitated prospective elucidation of the binding networks with residues located at <3.9 Å distance will enable the development of potent inhibitors suitable for the production of valuable alkaloid glucosides, Raucaffricine and strictosidine, by means of synthesis in Rauvolfia serpentina cell suspension cultures.

Raucaffricine Dilution Calculator

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Raucaffricine Molarity Calculator

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Preparing Stock Solutions of Raucaffricine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.951 mL 9.755 mL 19.5099 mL 39.0198 mL 48.7748 mL
5 mM 0.3902 mL 1.951 mL 3.902 mL 7.804 mL 9.755 mL
10 mM 0.1951 mL 0.9755 mL 1.951 mL 3.902 mL 4.8775 mL
50 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7804 mL 0.9755 mL
100 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.3902 mL 0.4877 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Raucaffricine

Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours.[Pubmed:25140865]

J Enzyme Inhib Med Chem. 2015 Jun;30(3):472-8.

Insight into the structure and inhibition mechanism of O-beta-d-glucosidases by deoxa-pyranosylamine type inhibitors is provided by X-ray analysis of complexes between Raucaffricine and strictosidine glucosidases and N-(cyclohexylmethyl)-, N-(cyclohexyl)- and N-(bromobenzyl)-beta-d-gluco-1,5-deoxa-pyranosylamine. All inhibitors anchored exclusively in the catalytic active site by competition with appropriate enzyme substrates. Thus facilitated prospective elucidation of the binding networks with residues located at <3.9 A distance will enable the development of potent inhibitors suitable for the production of valuable alkaloid glucosides, Raucaffricine and strictosidine, by means of synthesis in Rauvolfia serpentina cell suspension cultures.

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